TY - JOUR
T1 - KPC-9, a novel carbapenemase from clinical specimens in Israel
AU - Hidalgo-Grass, Carlos
AU - Warburg, Gabriela
AU - Temper, Violeta
AU - Benenson, Shmuel
AU - Moses, Allon E.
AU - Block, Colin
AU - Strahilevitz, Jacob
PY - 2012/11
Y1 - 2012/11
N2 - A blaKPC-9 carbapenemase variant was discovered in isolates of Klebsiella pneumoniae and Escherichia coli from a single patient. It differed from blaKPC-3 by one amino acid substitution (Val239Ala). The K. pneumoniae isolate was typed as ST258, as was the epidemic Israeli KPC-3 clone. blaKPC-9 was found on a plasmid indistinguishable from pKpQIL that carries blaKPC-3 in the epidemic clone. Compared to KPC-3, KPC-9 conferred less resistance to carbapenems and higher resistance to ceftazidime.
AB - A blaKPC-9 carbapenemase variant was discovered in isolates of Klebsiella pneumoniae and Escherichia coli from a single patient. It differed from blaKPC-3 by one amino acid substitution (Val239Ala). The K. pneumoniae isolate was typed as ST258, as was the epidemic Israeli KPC-3 clone. blaKPC-9 was found on a plasmid indistinguishable from pKpQIL that carries blaKPC-3 in the epidemic clone. Compared to KPC-3, KPC-9 conferred less resistance to carbapenems and higher resistance to ceftazidime.
UR - http://www.scopus.com/inward/record.url?scp=84868029394&partnerID=8YFLogxK
U2 - 10.1128/AAC.01156-12
DO - 10.1128/AAC.01156-12
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C2 - 22964247
AN - SCOPUS:84868029394
SN - 0066-4804
VL - 56
SP - 6057
EP - 6059
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 11
ER -
