KPC-9, a novel carbapenemase from clinical specimens in Israel

Carlos Hidalgo-Grass; Gabriela Warburg; Violeta Temper; Shmuel Benenson; Allon E. Moses; Colin Block; Jacob Strahilevitz

doi:10.1128/AAC.01156-12

KPC-9, a novel carbapenemase from clinical specimens in Israel

Carlos Hidalgo-Grass, Gabriela Warburg, Violeta Temper, Shmuel Benenson, Allon E. Moses, Colin Block, Jacob Strahilevitz^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

A bla_KPC-9 carbapenemase variant was discovered in isolates of Klebsiella pneumoniae and Escherichia coli from a single patient. It differed from bla_KPC-3 by one amino acid substitution (Val239Ala). The K. pneumoniae isolate was typed as ST258, as was the epidemic Israeli KPC-3 clone. bla_KPC-9 was found on a plasmid indistinguishable from pKpQIL that carries bla_KPC-3 in the epidemic clone. Compared to KPC-3, KPC-9 conferred less resistance to carbapenems and higher resistance to ceftazidime.

Original language	American English
Pages (from-to)	6057-6059
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	56
Issue number	11
DOIs	https://doi.org/10.1128/AAC.01156-12
State	Published - Nov 2012
Externally published	Yes

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title = "KPC-9, a novel carbapenemase from clinical specimens in Israel",

abstract = "A blaKPC-9 carbapenemase variant was discovered in isolates of Klebsiella pneumoniae and Escherichia coli from a single patient. It differed from blaKPC-3 by one amino acid substitution (Val239Ala). The K. pneumoniae isolate was typed as ST258, as was the epidemic Israeli KPC-3 clone. blaKPC-9 was found on a plasmid indistinguishable from pKpQIL that carries blaKPC-3 in the epidemic clone. Compared to KPC-3, KPC-9 conferred less resistance to carbapenems and higher resistance to ceftazidime.",

author = "Carlos Hidalgo-Grass and Gabriela Warburg and Violeta Temper and Shmuel Benenson and Moses, {Allon E.} and Colin Block and Jacob Strahilevitz",

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AU - Hidalgo-Grass, Carlos

AU - Warburg, Gabriela

AU - Temper, Violeta

AU - Benenson, Shmuel

AU - Moses, Allon E.

AU - Block, Colin

AU - Strahilevitz, Jacob

PY - 2012/11

Y1 - 2012/11

N2 - A blaKPC-9 carbapenemase variant was discovered in isolates of Klebsiella pneumoniae and Escherichia coli from a single patient. It differed from blaKPC-3 by one amino acid substitution (Val239Ala). The K. pneumoniae isolate was typed as ST258, as was the epidemic Israeli KPC-3 clone. blaKPC-9 was found on a plasmid indistinguishable from pKpQIL that carries blaKPC-3 in the epidemic clone. Compared to KPC-3, KPC-9 conferred less resistance to carbapenems and higher resistance to ceftazidime.

AB - A blaKPC-9 carbapenemase variant was discovered in isolates of Klebsiella pneumoniae and Escherichia coli from a single patient. It differed from blaKPC-3 by one amino acid substitution (Val239Ala). The K. pneumoniae isolate was typed as ST258, as was the epidemic Israeli KPC-3 clone. blaKPC-9 was found on a plasmid indistinguishable from pKpQIL that carries blaKPC-3 in the epidemic clone. Compared to KPC-3, KPC-9 conferred less resistance to carbapenems and higher resistance to ceftazidime.

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SN - 0066-4804

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JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 11

ER -

KPC-9, a novel carbapenemase from clinical specimens in Israel

Abstract

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