KPC-9, a novel carbapenemase from clinical specimens in Israel

Carlos Hidalgo-Grass, Gabriela Warburg, Violeta Temper, Shmuel Benenson, Allon E. Moses, Colin Block, Jacob Strahilevitz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


A blaKPC-9 carbapenemase variant was discovered in isolates of Klebsiella pneumoniae and Escherichia coli from a single patient. It differed from blaKPC-3 by one amino acid substitution (Val239Ala). The K. pneumoniae isolate was typed as ST258, as was the epidemic Israeli KPC-3 clone. blaKPC-9 was found on a plasmid indistinguishable from pKpQIL that carries blaKPC-3 in the epidemic clone. Compared to KPC-3, KPC-9 conferred less resistance to carbapenems and higher resistance to ceftazidime.

Original languageAmerican English
Pages (from-to)6057-6059
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Issue number11
StatePublished - Nov 2012
Externally publishedYes


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