TY - JOUR
T1 - L-Carnitine improves cognitive and renal functions in a rat model of chronic kidney disease
AU - Abu Ahmad, Nur
AU - Armaly, Zaher
AU - Berman, Sylvia
AU - Jabour, Adel
AU - Aga-Mizrachi, Shlomit
AU - Mosenego-Ornan, Efrat
AU - Avital, Avi
N1 - Publisher Copyright:
© 2016 Elsevier Inc..
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Over the past decade, the prevalence of chronic kidney disease (CKD) has reached epidemic proportions. The search for novel pharmacological treatment for CKD has become an area of intensive clinical research.l-Carnitine, considered as the "gatekeeper" responsible for admitting long chain fatty acids into cell mitochondria. l-Carnitine synthesis and turnover are regulated mainly by the kidney and its levels inversely correlate with serum creatinine of normal subjects and CKD patients.Previous studies showed that l-carnitine administration to elderly people is improving and preserving cognitive function. As yet, there are no clinical intervention studies that investigated the effect of l-carnitine administration on cognitive impairment evidenced in CKD patients.Thus, we aimed to investigate the effects of l-carnitine treatment on renal function and on the cognitive performance in a rat model of progressive CKD.To assess the role of l-carnitine on CKD condition, we estimated the renal function and cognitive abilities in a CKD rat model.We found that all CKD animals exhibited renal function deterioration, as indicated by elevated serum creatinine, BUN, and ample histopathological abnormalities. l-Carnitine treatment of CKD rats significantly reduced serum creatinine and BUN, attenuated renal hypertrophy and decreased renal tissue damage.In addition, in the two way shuttle avoidance learning, CKD animals showed cognitive impairment which recovered by the administration of l-carnitine.We conclude that in a rat model of CKD, l-carnitine administration significantly improved cognitive and renal functions.
AB - Over the past decade, the prevalence of chronic kidney disease (CKD) has reached epidemic proportions. The search for novel pharmacological treatment for CKD has become an area of intensive clinical research.l-Carnitine, considered as the "gatekeeper" responsible for admitting long chain fatty acids into cell mitochondria. l-Carnitine synthesis and turnover are regulated mainly by the kidney and its levels inversely correlate with serum creatinine of normal subjects and CKD patients.Previous studies showed that l-carnitine administration to elderly people is improving and preserving cognitive function. As yet, there are no clinical intervention studies that investigated the effect of l-carnitine administration on cognitive impairment evidenced in CKD patients.Thus, we aimed to investigate the effects of l-carnitine treatment on renal function and on the cognitive performance in a rat model of progressive CKD.To assess the role of l-carnitine on CKD condition, we estimated the renal function and cognitive abilities in a CKD rat model.We found that all CKD animals exhibited renal function deterioration, as indicated by elevated serum creatinine, BUN, and ample histopathological abnormalities. l-Carnitine treatment of CKD rats significantly reduced serum creatinine and BUN, attenuated renal hypertrophy and decreased renal tissue damage.In addition, in the two way shuttle avoidance learning, CKD animals showed cognitive impairment which recovered by the administration of l-carnitine.We conclude that in a rat model of CKD, l-carnitine administration significantly improved cognitive and renal functions.
KW - Chronic kidney disease
KW - Cognitive performance
KW - L-Carnitine
KW - Rat model
UR - http://www.scopus.com/inward/record.url?scp=84973332922&partnerID=8YFLogxK
U2 - 10.1016/j.physbeh.2016.05.036
DO - 10.1016/j.physbeh.2016.05.036
M3 - Article
C2 - 27241631
AN - SCOPUS:84973332922
SN - 0031-9384
VL - 164
SP - 182
EP - 188
JO - Physiology and Behavior
JF - Physiology and Behavior
ER -