TY - JOUR
T1 - Lack of Carcinogenicity of 4-, 5-, 6-, 7-, 8-, 9-, and 10-Hydroxybenzo(A)Pyrene on Mouse Skin
AU - Kapitulnik, Jaime
AU - Levin, Wayne
AU - Yagi, Haruhiko
AU - Jerina, Donald M.
AU - Conney, Allan H.
PY - 1976/10
Y1 - 1976/10
N2 - Seven phenols of benzo(a)pyrene (4-, 5-, 6-, 7-, 8-, 9-, and 10-hydroxybenzo(a)pyrene) were tested for carcinogenicity on mouse skin by application of 0.4 μmole of compound once every two weeks for 56 weeks. None of the seven phenols tested was carcinogenic to mouse skin, while treatment with the same dose of benzo(a)pyrene produced tumors in 92% of the treated animals. The lack of carcinogenicity of 7- and 8-hydroxybenzo(a)pyrene indicates that the strong carcinogenic activity previously reported for benzo(a)pyrene 7,8-oxide was not due to either phenolic isomerization product of this arene oxide.
AB - Seven phenols of benzo(a)pyrene (4-, 5-, 6-, 7-, 8-, 9-, and 10-hydroxybenzo(a)pyrene) were tested for carcinogenicity on mouse skin by application of 0.4 μmole of compound once every two weeks for 56 weeks. None of the seven phenols tested was carcinogenic to mouse skin, while treatment with the same dose of benzo(a)pyrene produced tumors in 92% of the treated animals. The lack of carcinogenicity of 7- and 8-hydroxybenzo(a)pyrene indicates that the strong carcinogenic activity previously reported for benzo(a)pyrene 7,8-oxide was not due to either phenolic isomerization product of this arene oxide.
UR - http://www.scopus.com/inward/record.url?scp=0017139212&partnerID=8YFLogxK
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 953988
AN - SCOPUS:0017139212
SN - 0008-5472
VL - 36
SP - 3625
EP - 3628
JO - Cancer Research
JF - Cancer Research
IS - 10
ER -