Lack of Carcinogenicity of 4-, 5-, 6-, 7-, 8-, 9-, and 10-Hydroxybenzo(A)Pyrene on Mouse Skin

Jaime Kapitulnik; Wayne Levin; Haruhiko Yagi; Donald M. Jerina; Allan H. Conney

Lack of Carcinogenicity of 4-, 5-, 6-, 7-, 8-, 9-, and 10-Hydroxybenzo(A)Pyrene on Mouse Skin

Jaime Kapitulnik^*
, Wayne Levin
, Haruhiko Yagi
, Donald M. Jerina
, Allan H. Conney

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Seven phenols of benzo(a)pyrene (4-, 5-, 6-, 7-, 8-, 9-, and 10-hydroxybenzo(a)pyrene) were tested for carcinogenicity on mouse skin by application of 0.4 μmole of compound once every two weeks for 56 weeks. None of the seven phenols tested was carcinogenic to mouse skin, while treatment with the same dose of benzo(a)pyrene produced tumors in 92% of the treated animals. The lack of carcinogenicity of 7- and 8-hydroxybenzo(a)pyrene indicates that the strong carcinogenic activity previously reported for benzo(a)pyrene 7,8-oxide was not due to either phenolic isomerization product of this arene oxide.

Original language	English
Pages (from-to)	3625-3628
Number of pages	4
Journal	Cancer Research
Volume	36
Issue number	10
State	Published - Oct 1976
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cite this

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title = "Lack of Carcinogenicity of 4-, 5-, 6-, 7-, 8-, 9-, and 10-Hydroxybenzo(A)Pyrene on Mouse Skin",

abstract = "Seven phenols of benzo(a)pyrene (4-, 5-, 6-, 7-, 8-, 9-, and 10-hydroxybenzo(a)pyrene) were tested for carcinogenicity on mouse skin by application of 0.4 μmole of compound once every two weeks for 56 weeks. None of the seven phenols tested was carcinogenic to mouse skin, while treatment with the same dose of benzo(a)pyrene produced tumors in 92\% of the treated animals. The lack of carcinogenicity of 7- and 8-hydroxybenzo(a)pyrene indicates that the strong carcinogenic activity previously reported for benzo(a)pyrene 7,8-oxide was not due to either phenolic isomerization product of this arene oxide.",

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AU - Kapitulnik, Jaime

AU - Levin, Wayne

AU - Yagi, Haruhiko

AU - Jerina, Donald M.

AU - Conney, Allan H.

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N2 - Seven phenols of benzo(a)pyrene (4-, 5-, 6-, 7-, 8-, 9-, and 10-hydroxybenzo(a)pyrene) were tested for carcinogenicity on mouse skin by application of 0.4 μmole of compound once every two weeks for 56 weeks. None of the seven phenols tested was carcinogenic to mouse skin, while treatment with the same dose of benzo(a)pyrene produced tumors in 92% of the treated animals. The lack of carcinogenicity of 7- and 8-hydroxybenzo(a)pyrene indicates that the strong carcinogenic activity previously reported for benzo(a)pyrene 7,8-oxide was not due to either phenolic isomerization product of this arene oxide.

AB - Seven phenols of benzo(a)pyrene (4-, 5-, 6-, 7-, 8-, 9-, and 10-hydroxybenzo(a)pyrene) were tested for carcinogenicity on mouse skin by application of 0.4 μmole of compound once every two weeks for 56 weeks. None of the seven phenols tested was carcinogenic to mouse skin, while treatment with the same dose of benzo(a)pyrene produced tumors in 92% of the treated animals. The lack of carcinogenicity of 7- and 8-hydroxybenzo(a)pyrene indicates that the strong carcinogenic activity previously reported for benzo(a)pyrene 7,8-oxide was not due to either phenolic isomerization product of this arene oxide.

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ER -

Lack of Carcinogenicity of 4-, 5-, 6-, 7-, 8-, 9-, and 10-Hydroxybenzo(A)Pyrene on Mouse Skin

Abstract

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