TY - JOUR
T1 - Lamins
T2 - Nuclear intermediate filament proteins with fundamental functions in nuclear mechanics and genome regulation
AU - Gruenbaum, Yosef
AU - Foisner, Roland
N1 - Publisher Copyright:
Copyright © 2015 by Annual Reviews. All rights reserved.
PY - 2015/6/2
Y1 - 2015/6/2
N2 - Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm. Lamins bind to a growing number of nuclear protein complexes and are implicated in both nuclear and cytoskeletal organization, mechanical stability, chromatin organization, gene regulation, genome stability, differentiation, and tissue-specific functions. The lamin-based complexes and their specific functions also provide insights into possible disease mechanisms for human laminopathies, ranging from muscular dystrophy to accelerated aging, as observed in Hutchinson-Gilford progeria and atypical Werner syndromes.
AB - Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm. Lamins bind to a growing number of nuclear protein complexes and are implicated in both nuclear and cytoskeletal organization, mechanical stability, chromatin organization, gene regulation, genome stability, differentiation, and tissue-specific functions. The lamin-based complexes and their specific functions also provide insights into possible disease mechanisms for human laminopathies, ranging from muscular dystrophy to accelerated aging, as observed in Hutchinson-Gilford progeria and atypical Werner syndromes.
KW - Chromatin
KW - Intermediate filament
KW - Laminopathies
KW - Lamins
KW - Nuclear envelope
KW - Nuclear mechanics
KW - Nuclear organization
UR - http://www.scopus.com/inward/record.url?scp=84930719986&partnerID=8YFLogxK
U2 - 10.1146/annurev-biochem-060614-034115
DO - 10.1146/annurev-biochem-060614-034115
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C2 - 25747401
AN - SCOPUS:84930719986
SN - 0066-4154
VL - 84
SP - 131
EP - 164
JO - Annual Review of Biochemistry
JF - Annual Review of Biochemistry
ER -