Lamins: Nuclear intermediate filament proteins with fundamental functions in nuclear mechanics and genome regulation

Yosef Gruenbaum, Roland Foisner

Research output: Contribution to journalArticlepeer-review

405 Scopus citations

Abstract

Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm. Lamins bind to a growing number of nuclear protein complexes and are implicated in both nuclear and cytoskeletal organization, mechanical stability, chromatin organization, gene regulation, genome stability, differentiation, and tissue-specific functions. The lamin-based complexes and their specific functions also provide insights into possible disease mechanisms for human laminopathies, ranging from muscular dystrophy to accelerated aging, as observed in Hutchinson-Gilford progeria and atypical Werner syndromes.

Original languageEnglish
Pages (from-to)131-164
Number of pages34
JournalAnnual Review of Biochemistry
Volume84
DOIs
StatePublished - 2 Jun 2015

Bibliographical note

Publisher Copyright:
Copyright © 2015 by Annual Reviews. All rights reserved.

Keywords

  • Chromatin
  • Intermediate filament
  • Laminopathies
  • Lamins
  • Nuclear envelope
  • Nuclear mechanics
  • Nuclear organization

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