Langerhans cells in the skin and oral mucosa: Brothers in arms?

Anna Brand; Avi Hai Hovav; Björn E. Clausen

doi:10.1002/eji.202149499

Langerhans cells in the skin and oral mucosa: Brothers in arms?

Anna Brand, Avi Hai Hovav, Björn E. Clausen^*

^*Corresponding author for this work

Institute of Biomedical Research at the Faculty of Dental Medicine

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

The skin and the oral mucosa represent interfaces to the environment that are constantly exposed to pathogens and harmless foreign antigens such as commensal bacteria. Both barrier organs share the presence of Langerhans cells (LC), distinctive members of the heterogeneous family of antigen-presenting dendritic cells (DC) that have the unique ability to promote tolerogenic as well as inflammatory immune responses. While skin LC have been extensively studied in the past decades, less is known about the function of oral mucosal LC. Despite similar transcriptomic signatures, skin and oral mucosal LC differ greatly in their ontogeny and development. In this review article, we will summarize the current knowledge on LC subsets in the skin compared to the oral mucosa. We will discuss the similarities and differences in their development, homeostasis, and function in the two barrier tissues, including their interaction with the local microbiota. In addition, this review will update recent advances on the role of LC in inflammatory skin and oral mucosal diseases.

Original language	American English
Article number	2149499
Journal	European Journal of Immunology
Volume	53
Issue number	7
DOIs	https://doi.org/10.1002/eji.202149499
State	Published - Jul 2023

Bibliographical note

Funding Information:
We thank members of the Clausen and the Hovav laboratories for fruitful discussions and Yasmin Netanely and Patrizia Stoitzner for critical reading of the manuscript. Work in the Clausen laboratory is supported by grants from the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) to B.E.C. (CL 419/2‐2 [Project Nr. 315501751], CL 419/4‐1, CL 419/7‐1 [Project Nr. 503972215], and SFB1292/2 TP20 [Project Nr. 318346496]), and B.E.C. is a member of the Research Center for Immunotherapy (Forschungszentrum Immuntherapie, FZI) of the University Medical Center Mainz.

Funding Information:
We thank members of the Clausen and the Hovav laboratories for fruitful discussions and Yasmin Netanely and Patrizia Stoitzner for critical reading of the manuscript. Work in the Clausen laboratory is supported by grants from the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) to B.E.C. (CL 419/2-2 [Project Nr. 315501751], CL 419/4-1, CL 419/7-1 [Project Nr. 503972215], and SFB1292/2 TP20 [Project Nr. 318346496]), and B.E.C. is a member of the Research Center for Immunotherapy (Forschungszentrum Immuntherapie, FZI) of the University Medical Center Mainz. Open access funding enabled and organized by Projekt DEAL.

Publisher Copyright:
© 2023 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.

Keywords

Immune regulation
Langerhans cells
Ontogeny
Oral epithelium
Skin epidermis

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10.1002/eji.202149499

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title = "Langerhans cells in the skin and oral mucosa: Brothers in arms?",

abstract = "The skin and the oral mucosa represent interfaces to the environment that are constantly exposed to pathogens and harmless foreign antigens such as commensal bacteria. Both barrier organs share the presence of Langerhans cells (LC), distinctive members of the heterogeneous family of antigen-presenting dendritic cells (DC) that have the unique ability to promote tolerogenic as well as inflammatory immune responses. While skin LC have been extensively studied in the past decades, less is known about the function of oral mucosal LC. Despite similar transcriptomic signatures, skin and oral mucosal LC differ greatly in their ontogeny and development. In this review article, we will summarize the current knowledge on LC subsets in the skin compared to the oral mucosa. We will discuss the similarities and differences in their development, homeostasis, and function in the two barrier tissues, including their interaction with the local microbiota. In addition, this review will update recent advances on the role of LC in inflammatory skin and oral mucosal diseases.",

keywords = "Immune regulation, Langerhans cells, Ontogeny, Oral epithelium, Skin epidermis",

author = "Anna Brand and Hovav, {Avi Hai} and Clausen, {Bj{\"o}rn E.}",

note = "Funding Information: We thank members of the Clausen and the Hovav laboratories for fruitful discussions and Yasmin Netanely and Patrizia Stoitzner for critical reading of the manuscript. Work in the Clausen laboratory is supported by grants from the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) to B.E.C. (CL 419/2‐2 [Project Nr. 315501751], CL 419/4‐1, CL 419/7‐1 [Project Nr. 503972215], and SFB1292/2 TP20 [Project Nr. 318346496]), and B.E.C. is a member of the Research Center for Immunotherapy (Forschungszentrum Immuntherapie, FZI) of the University Medical Center Mainz. Funding Information: We thank members of the Clausen and the Hovav laboratories for fruitful discussions and Yasmin Netanely and Patrizia Stoitzner for critical reading of the manuscript. Work in the Clausen laboratory is supported by grants from the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) to B.E.C. (CL 419/2-2 [Project Nr. 315501751], CL 419/4-1, CL 419/7-1 [Project Nr. 503972215], and SFB1292/2 TP20 [Project Nr. 318346496]), and B.E.C. is a member of the Research Center for Immunotherapy (Forschungszentrum Immuntherapie, FZI) of the University Medical Center Mainz. Open access funding enabled and organized by Projekt DEAL. Publisher Copyright: {\textcopyright} 2023 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.",

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AU - Hovav, Avi Hai

AU - Clausen, Björn E.

N1 - Funding Information: We thank members of the Clausen and the Hovav laboratories for fruitful discussions and Yasmin Netanely and Patrizia Stoitzner for critical reading of the manuscript. Work in the Clausen laboratory is supported by grants from the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) to B.E.C. (CL 419/2‐2 [Project Nr. 315501751], CL 419/4‐1, CL 419/7‐1 [Project Nr. 503972215], and SFB1292/2 TP20 [Project Nr. 318346496]), and B.E.C. is a member of the Research Center for Immunotherapy (Forschungszentrum Immuntherapie, FZI) of the University Medical Center Mainz. Funding Information: We thank members of the Clausen and the Hovav laboratories for fruitful discussions and Yasmin Netanely and Patrizia Stoitzner for critical reading of the manuscript. Work in the Clausen laboratory is supported by grants from the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) to B.E.C. (CL 419/2-2 [Project Nr. 315501751], CL 419/4-1, CL 419/7-1 [Project Nr. 503972215], and SFB1292/2 TP20 [Project Nr. 318346496]), and B.E.C. is a member of the Research Center for Immunotherapy (Forschungszentrum Immuntherapie, FZI) of the University Medical Center Mainz. Open access funding enabled and organized by Projekt DEAL. Publisher Copyright: © 2023 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.

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N2 - The skin and the oral mucosa represent interfaces to the environment that are constantly exposed to pathogens and harmless foreign antigens such as commensal bacteria. Both barrier organs share the presence of Langerhans cells (LC), distinctive members of the heterogeneous family of antigen-presenting dendritic cells (DC) that have the unique ability to promote tolerogenic as well as inflammatory immune responses. While skin LC have been extensively studied in the past decades, less is known about the function of oral mucosal LC. Despite similar transcriptomic signatures, skin and oral mucosal LC differ greatly in their ontogeny and development. In this review article, we will summarize the current knowledge on LC subsets in the skin compared to the oral mucosa. We will discuss the similarities and differences in their development, homeostasis, and function in the two barrier tissues, including their interaction with the local microbiota. In addition, this review will update recent advances on the role of LC in inflammatory skin and oral mucosal diseases.

AB - The skin and the oral mucosa represent interfaces to the environment that are constantly exposed to pathogens and harmless foreign antigens such as commensal bacteria. Both barrier organs share the presence of Langerhans cells (LC), distinctive members of the heterogeneous family of antigen-presenting dendritic cells (DC) that have the unique ability to promote tolerogenic as well as inflammatory immune responses. While skin LC have been extensively studied in the past decades, less is known about the function of oral mucosal LC. Despite similar transcriptomic signatures, skin and oral mucosal LC differ greatly in their ontogeny and development. In this review article, we will summarize the current knowledge on LC subsets in the skin compared to the oral mucosa. We will discuss the similarities and differences in their development, homeostasis, and function in the two barrier tissues, including their interaction with the local microbiota. In addition, this review will update recent advances on the role of LC in inflammatory skin and oral mucosal diseases.

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KW - Langerhans cells

KW - Ontogeny

KW - Oral epithelium

KW - Skin epidermis

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M3 - Review article

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AN - SCOPUS:85161392729

SN - 0014-2980

VL - 53

JO - European Journal of Immunology

JF - European Journal of Immunology

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M1 - 2149499

ER -

Langerhans cells in the skin and oral mucosa: Brothers in arms?

Abstract

Bibliographical note

Keywords

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