Large-scale analysis reveals acquisition of lineage-specific chromosomal aberrations in human adult stem cells

Uri Ben-David; Yoav Mayshar; Nissim Benvenisty

doi:10.1016/j.stem.2011.06.013

Large-scale analysis reveals acquisition of lineage-specific chromosomal aberrations in human adult stem cells

Uri Ben-David, Yoav Mayshar^*, Nissim Benvenisty

^*Corresponding author for this work

Department of Genetics

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209 Scopus citations

Abstract

In this study, we assessed the genetic integrity of over 400 samples of human multipotent stem cells using gene expression data sets. Our analysis reveals that neural and mesenchymal stem cells acquire characteristic large chromosomal aberrations at a similar, or somewhat lower, frequency to that seen in pluripotent stem cells, sometimes within a few passages in culture. Some of the identified chromosomal abnormalities can also be detected in human tumors of the respective tissues.

Original language	English
Pages (from-to)	97-102
Number of pages	6
Journal	Cell Stem Cell
Volume	9
Issue number	2
DOIs	https://doi.org/10.1016/j.stem.2011.06.013
State	Published - 5 Aug 2011

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abstract = "In this study, we assessed the genetic integrity of over 400 samples of human multipotent stem cells using gene expression data sets. Our analysis reveals that neural and mesenchymal stem cells acquire characteristic large chromosomal aberrations at a similar, or somewhat lower, frequency to that seen in pluripotent stem cells, sometimes within a few passages in culture. Some of the identified chromosomal abnormalities can also be detected in human tumors of the respective tissues.",

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Large-scale analysis reveals acquisition of lineage-specific chromosomal aberrations in human adult stem cells

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