Late-onset sarcoidosis after liver transplantation for primary biliary cirrhosis

Chamutal Gur, Gadi Lalazar, Victoria Doviner, Zvi G. Fridlender, Vered Molcho, Seif Abu-Much, Meir Shalit, Eran Elinav*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Primary biliary cirrhosis (PBC) and systemic sarcoidosis are granulomatous diseases of unknown etiology whose hepatic manifestations may infrequently be imitative of one another. Described herein is the first reported case in the medical literature of systemic sarcoidosis developing after liver transplantation for PBC. The presented patient, who suffered from typical clinical, laboratory, and pathologic manifestations of PBC, developed decompensated liver cirrhosis within a course of 8 years, necessitating orthotopic liver transplantation. A year and a half after transplantation, the patient developed diffuse, biopsy-proven, dermatologic and pulmonary manifestations of systemic sarcoidosis, which promptly responded to corticosteroid treatment. In retrospect, the patient's longstanding liver disease was probably caused by an unrecognizable, isolated hepatic form of sarcoidosis or an overlap between PBC and sarcoidosis. This patient illustrates the complexity that may be rarely encountered in differentiating between PBC and hepatic sarcoidosis. Discussed are the clinical, laboratory, and pathologic overlaps between hepatic sarcoidosis and PBC, and clues that may aid in the diagnosis and differentiation between the 2 disorders. Hepatologists and liver transplantation specialists should be aware of the rare possibility of hepatic sarcoidosis imitating PBC, and exacerbating systemically after liver transplantation.

Original languageAmerican English
Pages (from-to)329-332
Number of pages4
JournalJournal of Clinical Gastroenterology
Issue number3
StatePublished - Mar 2007
Externally publishedYes


  • Liver transplantation
  • Primary billiary cirrhosis
  • Sarcoidosis


Dive into the research topics of 'Late-onset sarcoidosis after liver transplantation for primary biliary cirrhosis'. Together they form a unique fingerprint.

Cite this