Late stillbirths and long-term mortality of mothers

Ronit Calderon-Margalit*, Yechiel Friedlander, Rivka Yanetz, Lisa Deutsch, Orly Manor, Susan Harlap, Ora Paltiel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

OBJECTIVE: To assess whether women who experienced stillbirths have an excess risk of long-term mortality. METHODS: We conducted a cohort study in the setting of the Jerusalem Perinatal Study, a population-based database of all births to West Jerusalem residents. Through data linkage with the Israeli Population Registry, we followed mothers who gave birth at least twice between 1964 and 1976 and compared the survival of women who had at least one stillbirth (n=595) with that of women who had only live births (n=24,523), using Cox proportional hazards models. RESULTS: During the study period, 78 (13.1%) mothers with stillbirths died, compared with 1,518 (6.2%) women without stillbirth (crude hazard ratio 2.08, 95% confidence interval [CI] 1.65-2.61). The mortality risk remained significantly increased after adjustments for sociodemographic variables, maternal diseases at pregnancy, placental abruption, and preeclampsia (hazard ratio 1.40, 95% CI 1.11-1.77). Stillbirth was associated with an increased risk of death from coronary heart disease (adjusted hazard ratio 2.00, 95% CI 1.02-3.93), all circulatory (adjusted hazard ratio 1.70, 95% CI 1.02-2.84) and renal (adjusted hazard ratio 4.70, 95% CI 1.47-15.0) causes. Stratifying by country of origin, an increased risk was evident particularly among women of North African origin (all-cause mortality, adjusted hazard ratio 2.47, 95% CI 1.69-3.63). CONCLUSION: Stillbirth may be a risk marker for premature mortality among parous women.

Original languageAmerican English
Pages (from-to)1301-1308
Number of pages8
JournalObstetrics and Gynecology
Volume109
Issue number6
DOIs
StatePublished - Jun 2007

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