LDL induces Saos2 osteoblast death via Akt pathways responsive to a neutral sphingomyelinase inhibitor

Keyphrases

• Osteoblast 100%
• Saos-2 100%
• Neutral Sphingomyelinase 100%
• Native LDL 100%
• Oxidized Low-density Lipoprotein (ox-LDL) 57%
• Src Kinase 42%
• Cell Death 42%
• Scyphostatin 42%
• Comorbidity 28%
• Caspase-9 28%
• Kinase Activity 28%
• Akt Phosphorylation 28%
• Glycogen Synthase Kinase 3 (GSK3) 28%
• Caspase-8 28%
• Forkhead 28%
• Apoptosis 14%
• Aging 14%
• Phosphorylation 14%
• Macrophages 14%
• Downstream Targets 14%
• Cell Proliferation 14%
• Cell Survival 14%
• Caspase-3 14%
• Ceramide 14%
• Growth Arrest 14%
• Induced Apoptosis 14%
• Pro-apoptotic 14%
• Induced Cell Death 14%
• Morphological Characteristics 14%
• Etiological Factors 14%
• Anti-apoptotic 14%
• Bcl-x 14%
• Vascular Wall 14%
• Postmenopausal Osteoporosis 14%
• Executor 14%
• Mitochondrial Apoptotic Pathway 14%
• Oxidized Low Density 14%
• Osteoblast Growth 14%

Pharmacology, Toxicology and Pharmaceutical Science

• Phosphotransferase 100%
• Sphingomyelin Phosphodiesterase Inhibitor 100%
• Receptor 66%
• Caspase 9 66%
• Glycogen Synthase Kinase 3 66%
• Sphingomyelin Phosphodiesterase 66%
• Comorbidity 66%
• Caspase 3 33%
• Caspase 8 33%
• Etiology 33%
• Growth Disorder 33%
• Antiapoptotic 33%
• Atherosclerosis 33%
• Ceramide 33%
• Postmenopause Osteoporosis 33%
• Caspase 8 Inhibitor 33%

Biochemistry, Genetics and Molecular Biology

• Osteoblast 100%
• Acid Sphingomyelinase 100%
• Sphingomyelin Phosphodiesterase 100%
• Cell Death 80%
• Phosphotransferase 60%
• Kinase 60%
• Caspase 8 40%
• Caspase-9 40%
• Saos-2 Cells 40%
• Glycogen Synthase Kinase 3 40%
• Comorbidity 40%
• Morphology 20%
• Cell Survival 20%
• Cell Proliferation 20%
• Macrophage 20%
• Caspase 3 20%
• Ceramide 20%