Learning-related population dynamics in the auditory thalamus

Ariel Gilad*, Ido Maor, Adi Mizrahi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Learning to associate sensory stimuli with a chosen action involves a dynamic interplay between cortical and thalamic circuits. While the cortex has been widely studied in this respect, how the thalamus encodes learning-related information is still largely unknown. We studied learning-related activity in the medial geniculate body (MGB; Auditory thalamus), targeting mainly the dorsal and medial regions. Using fiber photometry, we continuously imaged population calcium dynamics as mice learned a go/no-go auditory discrimination task. The MGB was tuned to frequency and responded to cognitive features like the choice of the mouse within several hundred milliseconds. Encoding of choice in the MGB increased with learning, and was highly correlated with the learning curves of the mice. MGB also encoded motor parameters of the mouse during the task. These results provide evidence that the MGB encodes task-motor-and learning-related information.

Original languageAmerican English
Article numbere56307
Pages (from-to)1-18
Number of pages18
JournaleLife
Volume9
DOIs
StatePublished - Jul 2020

Bibliographical note

Publisher Copyright:
© Gilad et al.

Fingerprint

Dive into the research topics of 'Learning-related population dynamics in the auditory thalamus'. Together they form a unique fingerprint.

Cite this