Abstract
Methylbenzethonium chloride (MBCl) decreased the growth of Leishmania major promastigotes and amastigotes in vitro. This decrease occurred during 4 days of exposure to the drug at concentrations of 0.1 to 2.5 μg ml-1. MBCl at 2 μg ml-1 killed almost 100% of the free living promastigotes and 87% of amastigotes within 4 days of treatment. Electron microscopy studies showed marked swelling of mitochondria in treated parasites. A possible additional effect on the parasite surface membrane is discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 1110-1116 |
| Number of pages | 7 |
| Journal | American Journal of Tropical Medicine and Hygiene |
| Volume | 35 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1986 |
| Externally published | Yes |