Lenticular effect in mice of some morphine-like drugs

Marta Weinstock; H. C. Stewart; K. R. Butterworth

doi:10.1038/1821519a0

Lenticular effect in mice of some morphine-like drugs

Marta Weinstock^*, H. C. Stewart, K. R. Butterworth

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

DRUG-INDUCED opacities of the lens of the eye have been recorded by Busche¹ using nitrophenol compounds in chicken. He was unable to produce this in any other small animals except in one particular strain of mice. While investigating the acute toxic effects of a series of reversed esters of pethidine, we observed that a number of these also produced an opacity. This was completely reversible and has been obtained by using other analgesic drugs in several strains of mice.

Original language	English
Pages (from-to)	1519-1520
Number of pages	2
Journal	Nature
Volume	182
Issue number	4648
DOIs	https://doi.org/10.1038/1821519a0
State	Published - 1958
Externally published	Yes

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title = "Lenticular effect in mice of some morphine-like drugs",

abstract = "DRUG-INDUCED opacities of the lens of the eye have been recorded by Busche1 using nitrophenol compounds in chicken. He was unable to produce this in any other small animals except in one particular strain of mice. While investigating the acute toxic effects of a series of reversed esters of pethidine, we observed that a number of these also produced an opacity. This was completely reversible and has been obtained by using other analgesic drugs in several strains of mice.",

author = "Marta Weinstock and Stewart, \{H. C.\} and Butterworth, \{K. R.\}",

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AB - DRUG-INDUCED opacities of the lens of the eye have been recorded by Busche1 using nitrophenol compounds in chicken. He was unable to produce this in any other small animals except in one particular strain of mice. While investigating the acute toxic effects of a series of reversed esters of pethidine, we observed that a number of these also produced an opacity. This was completely reversible and has been obtained by using other analgesic drugs in several strains of mice.

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Lenticular effect in mice of some morphine-like drugs

Abstract

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