TY - JOUR
T1 - Leptin administration affects growth and skeletal development in a rat intrauterine growth restriction model
T2 - Preliminary study
AU - Bar-El Dadon, Shimrit
AU - Shahar, Ron
AU - Katalan, Vered
AU - Monsonego-Ornan, Efrat
AU - Reifen, Ram
PY - 2011/9
Y1 - 2011/9
N2 - Objective: Skeletal abnormalities are one of the hallmarks of growth delay during gestation. The aim of this study was to determine changes induced by leptin in skeletal growth and development in a rat model of intrauterine growth retardation (IUGR) and to elucidate the possible underlying mechanisms. Methods: Intrauterine growth retardation was induced prepartum and the effects of leptin to mothers prenatally or to offspring postnatally were studied. Radii were harvested and tested mechanically and structurally. Tibias were evaluated for growth-plate morphometry. Results: On day 40 postpartum, total bone length and mineral density and tibial growth-plate width and numbers of cells within its zones of offspring treated with leptin were significantly greater than in the control group. Conclusion: Postnatal leptin administration in an IUGR model improves the structural properties and elongation rate of bone. These findings could pave the way to preventing some phenotypic presentations of IUGR.
AB - Objective: Skeletal abnormalities are one of the hallmarks of growth delay during gestation. The aim of this study was to determine changes induced by leptin in skeletal growth and development in a rat model of intrauterine growth retardation (IUGR) and to elucidate the possible underlying mechanisms. Methods: Intrauterine growth retardation was induced prepartum and the effects of leptin to mothers prenatally or to offspring postnatally were studied. Radii were harvested and tested mechanically and structurally. Tibias were evaluated for growth-plate morphometry. Results: On day 40 postpartum, total bone length and mineral density and tibial growth-plate width and numbers of cells within its zones of offspring treated with leptin were significantly greater than in the control group. Conclusion: Postnatal leptin administration in an IUGR model improves the structural properties and elongation rate of bone. These findings could pave the way to preventing some phenotypic presentations of IUGR.
KW - Bone
KW - Intrauterine growth retardation
KW - Leptin
KW - Mechanical testing
KW - Microcomputed tomography
KW - Rat model
UR - http://www.scopus.com/inward/record.url?scp=79960943859&partnerID=8YFLogxK
U2 - 10.1016/j.nut.2010.10.020
DO - 10.1016/j.nut.2010.10.020
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 21353474
AN - SCOPUS:79960943859
SN - 0899-9007
VL - 27
SP - 973
EP - 977
JO - Nutrition
JF - Nutrition
IS - 9
ER -