TY - JOUR
T1 - Leptin, insulin, and obesity-related phenotypes
T2 - Genetic influences on levels and longitudinal changes
AU - Friedlander, Yechiel
AU - Meiner, Vardiella
AU - Sharon, Nir
AU - Siscovick, David S.
AU - Miserez, Andre R.
PY - 2009/7
Y1 - 2009/7
N2 - This study estimated the genetic and environmental determinants of plasma leptin and insulin levels and of obesity-related phenotypes. Included in this analysis were family members from 80 families living in kibbutz settlements, who participated in two examinations 8-10 years apart. We estimated that polygenes explained 30-50% of the adjusted leptin and insulin levels and 30-70% of the anthropometric phenotypes. This study demonstrated a significant genetic influence on longitudinal changes in leptin and BMI (h 2 = 0.45) and small-to-moderate heritability estimates for changes in insulin and other obesity-related phenotypes. In bivariate genetic analyses, we observed positive genetic correlations between leptin and anthropometric phenotypes, suggesting that shared effects of the same sets of loci account for 20-30% of the additive genetic variance in these pairs of variables. Shared genetic factors also account for 20-25% of the additive genetic variance in insulin-anthropometric pairs of variables.
AB - This study estimated the genetic and environmental determinants of plasma leptin and insulin levels and of obesity-related phenotypes. Included in this analysis were family members from 80 families living in kibbutz settlements, who participated in two examinations 8-10 years apart. We estimated that polygenes explained 30-50% of the adjusted leptin and insulin levels and 30-70% of the anthropometric phenotypes. This study demonstrated a significant genetic influence on longitudinal changes in leptin and BMI (h 2 = 0.45) and small-to-moderate heritability estimates for changes in insulin and other obesity-related phenotypes. In bivariate genetic analyses, we observed positive genetic correlations between leptin and anthropometric phenotypes, suggesting that shared effects of the same sets of loci account for 20-30% of the additive genetic variance in these pairs of variables. Shared genetic factors also account for 20-25% of the additive genetic variance in insulin-anthropometric pairs of variables.
UR - http://www.scopus.com/inward/record.url?scp=67649726402&partnerID=8YFLogxK
U2 - 10.1038/oby.2008.672
DO - 10.1038/oby.2008.672
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C2 - 19214176
AN - SCOPUS:67649726402
SN - 1930-7381
VL - 17
SP - 1458
EP - 1460
JO - Obesity
JF - Obesity
IS - 7
ER -