Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1

Roi Gazit, Raizy Gruda, Moran Elboim, Tal I. Arnon, Gil Katz, Hagit Achdout, Jacob Hanna, Udi Qimron, Guy Landau, Evgenia Greenbaum, Zichria Zakay-Rones, Angel Porgador, Ofer Mandelboim*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

460 Scopus citations

Abstract

The elimination of viruses and tumors by natural killer cells is mediated by specific natural killer cell receptors. To study the in vivo function of a principal activating natural killer cell receptor, NCR1 (NKp46 in humans), we replaced the gene encoding this receptor (Ncr1) with a green fluorescent protein reporter cassette. There was enhanced spread of certain tumors in 129/Sv but not C57BL/6 Ncr1gfp/gfp mice, and influenza virus infection was lethal in both 129/Sv and C57BL/ 6 Ncr1gfp/gfp mice. We noted accumulation of natural killer cells at the site of influenza infection by tracking the green fluorescent protein. Our results demonstrate a critical function for Ncr1 in the in vivo eradication of influenza virus.

Original languageAmerican English
Pages (from-to)517-523
Number of pages7
JournalNature Immunology
Volume7
Issue number5
DOIs
StatePublished - May 2006

Bibliographical note

Funding Information:
Supported by the Israel Science Foundation (O.M.), the Binational Science Foundation (O.M.), the Israel Ministry of Health and the European Commission (LSHC-CT-2002-518178 to O.M.).

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