Leukocyte CD300a Contributes to the Resolution of Murine Allergic Inflammation

Laila Karra, Roopesh Singh Gangwar, Revital Shamri, Pier Giorgio Puzzovio, Shahar Cohen-Mor, Bruce D. Levy, Francesca Levi-Schaffer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential roles in the resolution of AI are still to be determined. In this study, employing a mouse model of allergic peritonitis, we demonstrate that CD300a expression on peritoneal cells is regulated from inflammation to resolution. Allergic peritonitis-induced CD300a2/2 mice had a rapid increase in their inflammatory cell infiltrates and tryptase content in the peritoneal cavity compared with wild type, and their resolution process was significantly delayed. CD300a2/2 mice expressed lower levels of ALX/FPR2 receptor on peritoneal cells and had higher levels of LXA4 in the peritoneal lavage. CD300a activation on mouse bone marrow-derived mast cells regulated ALX/FPR2 expression levels following IgE-mediated activation. Together, these findings indicate a role for CD300a in AI and its resolution, in part via the specialized proresolving mediator LXA4 and ALX/FPR2 receptor pathway activation. The Journal of Immunology, 2018, 201: 2998-3005.

Original languageAmerican English
Pages (from-to)2998-3005
Number of pages8
JournalJournal of Immunology
Volume201
Issue number10
DOIs
StatePublished - 15 Nov 2018

Bibliographical note

Publisher Copyright:
Copyright © 2018 by The American Association of Immunologists, Inc. All rights reserved

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