Ligand induced half-of-the-sites reactivity in rabbit muscle glyceraldehyde-3-phosphate dehydrogenase

Alexander Levitzki

doi:10.1016/0006-291X(73)90777-8

Ligand induced half-of-the-sites reactivity in rabbit muscle glyceraldehyde-3-phosphate dehydrogenase

Alexander Levitzki^*

^*Corresponding author for this work

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Abstract

ApoGPDH is shown to exhibit half-of-the-sites reactivity towards iodeacetamido-naphthal (IAN) and FDNB and all-of-the-sites reactivity towards DTNB, iodoactic acid and the large DDPM molecule. It is suggested that the asymmetry in the ApoGPDH molecule is induced by some alkylating reagents and not by others, depending on the nature of the interaction between the alkyl group and the active site of the enzyme.

Original language	English
Pages (from-to)	889-893
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	54
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(73)90777-8
State	Published - 1 Oct 1973
Externally published	Yes

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title = "Ligand induced half-of-the-sites reactivity in rabbit muscle glyceraldehyde-3-phosphate dehydrogenase",

abstract = "ApoGPDH is shown to exhibit half-of-the-sites reactivity towards iodeacetamido-naphthal (IAN) and FDNB and all-of-the-sites reactivity towards DTNB, iodoactic acid and the large DDPM molecule. It is suggested that the asymmetry in the ApoGPDH molecule is induced by some alkylating reagents and not by others, depending on the nature of the interaction between the alkyl group and the active site of the enzyme.",

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AB - ApoGPDH is shown to exhibit half-of-the-sites reactivity towards iodeacetamido-naphthal (IAN) and FDNB and all-of-the-sites reactivity towards DTNB, iodoactic acid and the large DDPM molecule. It is suggested that the asymmetry in the ApoGPDH molecule is induced by some alkylating reagents and not by others, depending on the nature of the interaction between the alkyl group and the active site of the enzyme.

UR - https://www.scopus.com/pages/publications/0015891136

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IS - 3

ER -

Ligand induced half-of-the-sites reactivity in rabbit muscle glyceraldehyde-3-phosphate dehydrogenase

Abstract

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