Light-Oxygen-Voltage (LOV)-sensing Domains: Activation Mechanism and Optogenetic Stimulation

Andrea Flores-Ibarra, Raiza N.A. Maia, Bence Olasz, Jonathan R. Church, Guillaume Gotthard, Igor Schapiro, Joachim Heberle, Przemyslaw Nogly*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

The light-oxygen-voltage (LOV) domains of phototropins emerged as essential constituents of light-sensitive proteins, helping initiate blue light-triggered responses. Moreover, these domains have been identified across all kingdoms of life. LOV domains utilize flavin nucleotides as co-factors and undergo structural rearrangements upon exposure to blue light, which activates an effector domain that executes the final output of the photoreaction. LOV domains are versatile photoreceptors that play critical roles in cellular signaling and environmental adaptation; additionally, they can noninvasively sense and control intracellular processes with high spatiotemporal precision, making them ideal candidates for use in optogenetics, where a light signal is linked to a cellular process through a photoreceptor. The ongoing development of LOV-based optogenetic tools, driven by advances in structural biology, spectroscopy, computational methods, and synthetic biology, has the potential to revolutionize the study of biological systems and enable the development of novel therapeutic strategies.

Original languageAmerican English
Article number168356
JournalJournal of Molecular Biology
Volume436
Issue number5
DOIs
StatePublished - 1 Mar 2024

Bibliographical note

Publisher Copyright:
© 2023 The Author(s)

Keywords

  • LOV
  • molecular mechanism
  • optogenetics
  • photoreceptor
  • signal transduction

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