TY - JOUR
T1 - Light-responsive arylazopyrazole-based hydrogels
T2 - Their applications as shape-memory materials, self-healing matrices and controlled drug release systems
AU - Davidson-Rozenfeld, Gilad
AU - Stricker, Lucas
AU - Simke, Julian
AU - Fadeev, Michael
AU - Vázquez-González, Margarita
AU - Ravoo, Bart Jan
AU - Willner, Itamar
N1 - Publisher Copyright:
© 2019 The Royal Society of Chemistry.
PY - 2019/8/14
Y1 - 2019/8/14
N2 - Carboxymethyl cellulose (CMC) chains functionalized only with β-cyclodextrin (β-CD), or with nucleic acids, β-CD and photoisomerizable arylazopyrazole (AAP), self-assemble into stimuli-responsive hydrogels which reveal stiffness-controlled properties. In the first system, β-CD modified CMC chains crosslinked by trans-bis-AAP (1) result in a hydrogel that can be switched between low-stiffness and high-stiffness states in response to alternating photoisomerization between trans-bis-AAP/cis-bis-AAP. In the second system, the CMC scaffold is modified with β-CD units, AAP and self-complementary nucleic acid (2) as tethers, leading to a high-stiffness hydrogel, cooperatively crosslinked by β-CD/trans-AAP and (2)/(2) duplexes. By alternating the photoisomerization of trans-AAP units to cis-AAP and back, the hydrogel is cycled between low-stiffness and high-stiffness states. In the third system, the use of G-quadruplexes as crosslinking motifs that respond to chemical triggers results in a hydrogel that reveals dual triggered stiffness properties, stimulated by light or K+-ions/crown-ether. The hybrid hydrogels are applied as light-responsive and dual triggered shape-memory, self-healing and controlled drug-release materials.
AB - Carboxymethyl cellulose (CMC) chains functionalized only with β-cyclodextrin (β-CD), or with nucleic acids, β-CD and photoisomerizable arylazopyrazole (AAP), self-assemble into stimuli-responsive hydrogels which reveal stiffness-controlled properties. In the first system, β-CD modified CMC chains crosslinked by trans-bis-AAP (1) result in a hydrogel that can be switched between low-stiffness and high-stiffness states in response to alternating photoisomerization between trans-bis-AAP/cis-bis-AAP. In the second system, the CMC scaffold is modified with β-CD units, AAP and self-complementary nucleic acid (2) as tethers, leading to a high-stiffness hydrogel, cooperatively crosslinked by β-CD/trans-AAP and (2)/(2) duplexes. By alternating the photoisomerization of trans-AAP units to cis-AAP and back, the hydrogel is cycled between low-stiffness and high-stiffness states. In the third system, the use of G-quadruplexes as crosslinking motifs that respond to chemical triggers results in a hydrogel that reveals dual triggered stiffness properties, stimulated by light or K+-ions/crown-ether. The hybrid hydrogels are applied as light-responsive and dual triggered shape-memory, self-healing and controlled drug-release materials.
UR - http://www.scopus.com/inward/record.url?scp=85070239951&partnerID=8YFLogxK
U2 - 10.1039/c9py00559e
DO - 10.1039/c9py00559e
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AN - SCOPUS:85070239951
SN - 1759-9954
VL - 10
SP - 4106
EP - 4115
JO - Polymer Chemistry
JF - Polymer Chemistry
IS - 30
ER -