Lighting up biochemiluminescence by the surface self-assembly of DNA - Hemin complexes

Yi Xiao; Valeri Pavlov; Ron Gill; Tatyana Bourenko; Itamar Willner

doi:10.1002/cbic.200300794

Lighting up biochemiluminescence by the surface self-assembly of DNA - Hemin complexes

Yi Xiao
, Valeri Pavlov
, Ron Gill
, Tatyana Bourenko
, Itamar Willner^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

172 Scopus citations

Abstract

Illuminating DNA: The assembly of two tailored nucleic acids (colored blue and brown in the scheme) in the presence of hemin yields a G-quadruplex that exhibits peroxidase-like activity and catalyzes the generation of chemiluminescence in the presence of H₂O₂ and luminol. The DNAzyme is employed for the analysis of DNA (green) in solution and on surfaces.

Original language	English
Pages (from-to)	374-379
Number of pages	6
Journal	ChemBioChem
Volume	5
Issue number	3
DOIs	https://doi.org/10.1002/cbic.200300794
State	Published - 5 Mar 2004

Keywords

Biocatalysis
DNA
Hemin
Luminescence
Monolayers
Self-assembly

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abstract = "Illuminating DNA: The assembly of two tailored nucleic acids (colored blue and brown in the scheme) in the presence of hemin yields a G-quadruplex that exhibits peroxidase-like activity and catalyzes the generation of chemiluminescence in the presence of H2O2 and luminol. The DNAzyme is employed for the analysis of DNA (green) in solution and on surfaces.",

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AU - Willner, Itamar

PY - 2004/3/5

Y1 - 2004/3/5

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KW - Biocatalysis

KW - DNA

KW - Hemin

KW - Luminescence

KW - Monolayers

KW - Self-assembly

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Lighting up biochemiluminescence by the surface self-assembly of DNA - Hemin complexes

Abstract

Keywords

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