Limbic Activity Modulation Guided by Functional Magnetic Resonance Imaging–Inspired Electroencephalography Improves Implicit Emotion Regulation

Jackob N. Keynan; Yehudit Meir-Hasson; Gadi Gilam; Avihay Cohen; Gilan Jackont; Sivan Kinreich; Limor Ikar; Ayelet Or-Borichev; Amit Etkin; Anett Gyurak; Ilana Klovatch; Nathan Intrator; Talma Hendler

doi:10.1016/j.biopsych.2015.12.024

Limbic Activity Modulation Guided by Functional Magnetic Resonance Imaging–Inspired Electroencephalography Improves Implicit Emotion Regulation

Jackob N. Keynan, Yehudit Meir-Hasson, Gadi Gilam, Avihay Cohen, Gilan Jackont, Sivan Kinreich, Limor Ikar, Ayelet Or-Borichev, Amit Etkin, Anett Gyurak, Ilana Klovatch, Nathan Intrator, Talma Hendler^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

The amygdala has a pivotal role in processing traumatic stress; hence, gaining control over its activity could facilitate adaptive mechanism and recovery. To date, amygdala volitional regulation could be obtained only via real-time functional magnetic resonance imaging (fMRI), a highly inaccessible procedure. The current article presents high-impact neurobehavioral implications of a novel imaging approach that enables bedside monitoring of amygdala activity using fMRI-inspired electroencephalography (EEG), hereafter termed amygdala-electrical fingerprint (amyg-EFP). Simultaneous EEG/fMRI indicated that the amyg-EFP reliably predicts amygdala-blood oxygen level–dependent activity. Implementing the amyg-EFP in neurofeedback demonstrated that learned downregulation of the amyg-EFP facilitated volitional downregulation of amygdala-blood oxygen level–dependent activity via real-time fMRI and manifested as reduced amygdala reactivity to visual stimuli. Behavioral evidence further emphasized the therapeutic potential of this approach by showing improved implicit emotion regulation following amyg-EFP neurofeedback. Additional EFP models denoting different brain regions could provide a library of localized activity for low-cost and highly accessible brain-based diagnosis and treatment.

Original language	English
Pages (from-to)	490-496
Number of pages	7
Journal	Biological Psychiatry
Volume	80
Issue number	6
DOIs	https://doi.org/10.1016/j.biopsych.2015.12.024
State	Published - 15 Sep 2016
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2016 Society of Biological Psychiatry

Keywords

Amygdala
Brain-computer interface
EEG neurofeedback
Machine learning
Real-time fMRI
Stress

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10.1016/j.biopsych.2015.12.024

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Keynan, J. N., Meir-Hasson, Y., Gilam, G., Cohen, A., Jackont, G., Kinreich, S., Ikar, L., Or-Borichev, A., Etkin, A., Gyurak, A., Klovatch, I., Intrator, N., & Hendler, T. (2016). Limbic Activity Modulation Guided by Functional Magnetic Resonance Imaging–Inspired Electroencephalography Improves Implicit Emotion Regulation. Biological Psychiatry, 80(6), 490-496. https://doi.org/10.1016/j.biopsych.2015.12.024

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abstract = "The amygdala has a pivotal role in processing traumatic stress; hence, gaining control over its activity could facilitate adaptive mechanism and recovery. To date, amygdala volitional regulation could be obtained only via real-time functional magnetic resonance imaging (fMRI), a highly inaccessible procedure. The current article presents high-impact neurobehavioral implications of a novel imaging approach that enables bedside monitoring of amygdala activity using fMRI-inspired electroencephalography (EEG), hereafter termed amygdala-electrical fingerprint (amyg-EFP). Simultaneous EEG/fMRI indicated that the amyg-EFP reliably predicts amygdala-blood oxygen level–dependent activity. Implementing the amyg-EFP in neurofeedback demonstrated that learned downregulation of the amyg-EFP facilitated volitional downregulation of amygdala-blood oxygen level–dependent activity via real-time fMRI and manifested as reduced amygdala reactivity to visual stimuli. Behavioral evidence further emphasized the therapeutic potential of this approach by showing improved implicit emotion regulation following amyg-EFP neurofeedback. Additional EFP models denoting different brain regions could provide a library of localized activity for low-cost and highly accessible brain-based diagnosis and treatment.",

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Keynan, JN, Meir-Hasson, Y, Gilam, G, Cohen, A, Jackont, G, Kinreich, S, Ikar, L, Or-Borichev, A, Etkin, A, Gyurak, A, Klovatch, I, Intrator, N & Hendler, T 2016, 'Limbic Activity Modulation Guided by Functional Magnetic Resonance Imaging–Inspired Electroencephalography Improves Implicit Emotion Regulation', Biological Psychiatry, vol. 80, no. 6, pp. 490-496. https://doi.org/10.1016/j.biopsych.2015.12.024

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AU - Intrator, Nathan

AU - Hendler, Talma

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Limbic Activity Modulation Guided by Functional Magnetic Resonance Imaging–Inspired Electroencephalography Improves Implicit Emotion Regulation

Abstract

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Keywords

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