Linking DNA methylation and histone modification: Patterns and paradigms

Howard Cedar*, Yehudit Bergman

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1793 Scopus citations

Abstract

Both DNA methylation and histone modification are involved in establishing patterns of gene repression during development. Certain forms of histone methylation cause local formation of heterochromatin, which is readily reversible, whereas DNA methylation leads to stable long-term repression. It has recently become apparent that DNA methylation and histone modification pathways can be dependent on one another, and that this crosstalk can be mediated by biochemical interactions between SET domain histone methyltransferases and DNA methyltransferases. Relationships between DNA methylation and histone modification have implications for understanding normal development as well as somatic cell reprogramming and tumorigenesis.

Original languageAmerican English
Pages (from-to)295-304
Number of pages10
JournalNature Reviews Genetics
Volume10
Issue number5
DOIs
StatePublished - May 2009

Bibliographical note

Funding Information:
This work was supported by grants from the Israel Academy of Science (Y.B. and H.C.), the National Institutes of Health (Y.B. and H.C.), the Israel Cancer Research Fund (Y.B. and H.C.) and Lew Sherman (H.C.).

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