Lipid Assemblies at the Crossroads of Aging, Proteostasis, and Neurodegeneration

Noa Roitenberg, Ehud Cohen*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

The proteostasis network (PN) is a nexus of mechanisms that act in concert to maintain the integrity of the proteome. Efficiency of the PN declines with age, resulting in the accumulation of misfolded proteins, and in some cases in the development of neurodegenerative disorders. Thus, maintaining an active and efficient PN through the late stages of life could delay or prevent neurodegeneration. Indeed, altering the activity of aging-regulating pathways protects model organisms from neurodegeneration-linked toxic protein aggregation. Here, we delineate evidence that the formation and integrity of lipid assemblies are affected by aging-regulating pathways, and describe the roles of these structures in proteostasis maintenance. We also highlight future research directions and discuss the possibility that compounds which modulate lipid assemblies could be used for the treatment of neurodegenerative disorders.

Original languageAmerican English
Pages (from-to)954-963
Number of pages10
JournalTrends in Cell Biology
Volume29
Issue number12
DOIs
StatePublished - Dec 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Ltd

Keywords

  • aging
  • insulin/IGF signaling
  • lipid assemblies
  • neurodegeneration
  • proteostasis

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