Lithium inhibition of adrenaline-stimulated adenylate cyclase in humans

Richard Ebstein; Robert Belmaker; Leon Grunhaus; Ranan Rimon

doi:10.1038/259411a0

Lithium inhibition of adrenaline-stimulated adenylate cyclase in humans

Richard Ebstein^*
, Robert Belmaker
, Leon Grunhaus
, Ranan Rimon

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

96 Scopus citations

Abstract

LITHIUM is an effective therapeutic agent in the treatment and prevention of the manic phase of manic-depression¹, and although known to influence many physiological systems, no specific mechanism has been identified for its efficacy in this illness². One postulated primary site of Li action is as an inhibitor of hormone-stimulated adenylate cyclase³. Li inhibits the ADH-sensitive adenylate cyclase in kidney^4,5, the TSH-sensitive adenylate cyclase in thyroid^6,7, the prostaglandin-sensitive adenylate cyclase in human platelets^8,9, and the noradrenaline-sensitive adenylate cyclase in rat brain^10,11.

Original language	English
Pages (from-to)	411-413
Number of pages	3
Journal	Nature
Volume	259
Issue number	5542
DOIs	https://doi.org/10.1038/259411a0
State	Published - 1976
Externally published	Yes

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abstract = "LITHIUM is an effective therapeutic agent in the treatment and prevention of the manic phase of manic-depression1, and although known to influence many physiological systems, no specific mechanism has been identified for its efficacy in this illness2. One postulated primary site of Li action is as an inhibitor of hormone-stimulated adenylate cyclase3. Li inhibits the ADH-sensitive adenylate cyclase in kidney4,5, the TSH-sensitive adenylate cyclase in thyroid6,7, the prostaglandin-sensitive adenylate cyclase in human platelets8,9, and the noradrenaline-sensitive adenylate cyclase in rat brain10,11.",

author = "Richard Ebstein and Robert Belmaker and Leon Grunhaus and Ranan Rimon",

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doi = "10.1038/259411a0",

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AU - Belmaker, Robert

AU - Grunhaus, Leon

AU - Rimon, Ranan

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Lithium inhibition of adrenaline-stimulated adenylate cyclase in humans

Abstract

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