Liver regeneration induced by a designer human IL-6/sIL-6R fusion protein reverses severe hepatocellular injury

Eithan Galun; Evelyn Zeira; Orit Pappo; Malte Peters; Stefan Rose-John

doi:10.1096/fj.99-0913com

Liver regeneration induced by a designer human IL-6/sIL-6R fusion protein reverses severe hepatocellular injury

Eithan Galun^*, Evelyn Zeira, Orit Pappo, Malte Peters, Stefan Rose-John

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Abstract

The cytokine IL-6 plays a significant role in liver regeneration in conjunction with additional growth factors (HGF, TNF-α, and TGF-α). Many IL-6 effects depend on a naturally occurring soluble IL-6 receptor (sIL-6R). Here, the chimeric protein hyper-IL-6, constructed from the human IL-6 protein fused to a truncated form of its receptor, was found to have superagonistic IL-6 properties, and as such, enhanced liver cell regeneration. Hyper-IL-6 reversed the state of hepatotoxicity and enhanced the survival rates of rats suffering from fulminant hepatic failure after D-galactosamine administration. The hyper-IL-6 protein has a significant potential for use in the treatment of severe human liver diseases.

Original language	English
Pages (from-to)	1979-1987
Number of pages	9
Journal	FASEB Journal
Volume	14
Issue number	13
DOIs	https://doi.org/10.1096/fj.99-0913com
State	Published - 2000
Externally published	Yes

Keywords

Chimeric protein
Cytokines
Hepatotoxicity
Hyper-IL-6
Interleukin 6
Liver failure

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title = "Liver regeneration induced by a designer human IL-6/sIL-6R fusion protein reverses severe hepatocellular injury",

abstract = "The cytokine IL-6 plays a significant role in liver regeneration in conjunction with additional growth factors (HGF, TNF-α, and TGF-α). Many IL-6 effects depend on a naturally occurring soluble IL-6 receptor (sIL-6R). Here, the chimeric protein hyper-IL-6, constructed from the human IL-6 protein fused to a truncated form of its receptor, was found to have superagonistic IL-6 properties, and as such, enhanced liver cell regeneration. Hyper-IL-6 reversed the state of hepatotoxicity and enhanced the survival rates of rats suffering from fulminant hepatic failure after D-galactosamine administration. The hyper-IL-6 protein has a significant potential for use in the treatment of severe human liver diseases.",

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AU - Galun, Eithan

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AU - Pappo, Orit

AU - Peters, Malte

AU - Rose-John, Stefan

PY - 2000

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AB - The cytokine IL-6 plays a significant role in liver regeneration in conjunction with additional growth factors (HGF, TNF-α, and TGF-α). Many IL-6 effects depend on a naturally occurring soluble IL-6 receptor (sIL-6R). Here, the chimeric protein hyper-IL-6, constructed from the human IL-6 protein fused to a truncated form of its receptor, was found to have superagonistic IL-6 properties, and as such, enhanced liver cell regeneration. Hyper-IL-6 reversed the state of hepatotoxicity and enhanced the survival rates of rats suffering from fulminant hepatic failure after D-galactosamine administration. The hyper-IL-6 protein has a significant potential for use in the treatment of severe human liver diseases.

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KW - Cytokines

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KW - Interleukin 6

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Liver regeneration induced by a designer human IL-6/sIL-6R fusion protein reverses severe hepatocellular injury

Abstract

Keywords

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