Liver regeneration induced by a designer human IL-6/sIL-6R fusion protein reverses severe hepatocellular injury

Eithan Galun*, Evelyn Zeira, Orit Pappo, Malte Peters, Stefan Rose-John

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

110 Scopus citations

Abstract

The cytokine IL-6 plays a significant role in liver regeneration in conjunction with additional growth factors (HGF, TNF-α, and TGF-α). Many IL-6 effects depend on a naturally occurring soluble IL-6 receptor (sIL-6R). Here, the chimeric protein hyper-IL-6, constructed from the human IL-6 protein fused to a truncated form of its receptor, was found to have superagonistic IL-6 properties, and as such, enhanced liver cell regeneration. Hyper-IL-6 reversed the state of hepatotoxicity and enhanced the survival rates of rats suffering from fulminant hepatic failure after D-galactosamine administration. The hyper-IL-6 protein has a significant potential for use in the treatment of severe human liver diseases.

Original languageAmerican English
Pages (from-to)1979-1987
Number of pages9
JournalFASEB Journal
Volume14
Issue number13
DOIs
StatePublished - 2000
Externally publishedYes

Keywords

  • Chimeric protein
  • Cytokines
  • Hepatotoxicity
  • Hyper-IL-6
  • Interleukin 6
  • Liver failure

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