Abstract
The cytokine IL-6 plays a significant role in liver regeneration in conjunction with additional growth factors (HGF, TNF-α, and TGF-α). Many IL-6 effects depend on a naturally occurring soluble IL-6 receptor (sIL-6R). Here, the chimeric protein hyper-IL-6, constructed from the human IL-6 protein fused to a truncated form of its receptor, was found to have superagonistic IL-6 properties, and as such, enhanced liver cell regeneration. Hyper-IL-6 reversed the state of hepatotoxicity and enhanced the survival rates of rats suffering from fulminant hepatic failure after D-galactosamine administration. The hyper-IL-6 protein has a significant potential for use in the treatment of severe human liver diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 1979-1987 |
| Number of pages | 9 |
| Journal | FASEB Journal |
| Volume | 14 |
| Issue number | 13 |
| DOIs | |
| State | Published - 2000 |
| Externally published | Yes |
Keywords
- Chimeric protein
- Cytokines
- Hepatotoxicity
- Hyper-IL-6
- Interleukin 6
- Liver failure
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