lncRNAs in fertility: redefining the gene expression paradigm?

Yonatan B. Tzur*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Comparative transcriptome approaches assume that highly or dynamically expressed genes are important. This has led to the identification of many genes critical for cellular activity and organism development. However, while testes express the highest levels of long noncoding RNAs (lncRNAs), there is scarcely any evidence for lncRNAs with significant roles in fertility. This was explained by changes in chromatin structure during spermatogenesis that lead to ‘promiscuous transcription’ with no functional roles for the transcripts. Recent discoveries offer novel and surprising alternatives. Here, I review the current knowledge regarding the involvement of lncRNAs in fertility, why I find gametogenesis different from other developmental processes, offer models to explain why the experimental evidence did not meet theoretical predictions, and suggest possible approaches to test the models.

Original languageAmerican English
Pages (from-to)1170-1179
Number of pages10
JournalTrends in Genetics
Issue number11
StatePublished - Nov 2022

Bibliographical note

Funding Information:
I thank the members of the Tzur laboratory, Daniel Sher and Noa Sher, for their help in discussing and proofreading the manuscript and Yarden Ben-Tabou de-Leon for professional graphic work. This work was supported by the Israel Science Foundation (grant number 979/21 ), Ministry of Science and Technology, Israel (grant number 100594 ), and the Shemesh Fund.

Publisher Copyright:
© 2022 Elsevier Ltd


  • fertility
  • lincRNA
  • lncRNA
  • meiosis
  • spermatogenesis


Dive into the research topics of 'lncRNAs in fertility: redefining the gene expression paradigm?'. Together they form a unique fingerprint.

Cite this