Local SIgA response following administration of a novel intranasal inactivated influenza virus vaccine in community residing elderly

M. Muszkat, G. Friedman, M. H. Schein, P. Naveh, E. Greenbaum, M. Schlesinger, Z. Zakay-Rones, A. Ben Yehuda

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Community-residing elderly were immunized twice intranasally three weeks apart with a new inactivated whole influenza vaccine. A control group was immunized intramuscularly with conventional influenza vaccine. Local antibody response was detected in about 50% of intranasally immunized subjects compared to about 20% of intramuscularly immunized subjects, to the three viral strains. Increasing the incidence of elevated IgA response may prevent influenza at its early stages thus reducing complications in the elderly. (C) 2000 Elsevier Science Ltd.

Original languageAmerican English
Pages (from-to)1696-1699
Number of pages4
JournalVaccine
Volume18
Issue number16
DOIs
StatePublished - 25 Feb 2000
Externally publishedYes

Keywords

  • Elderly
  • Inactive influenza vaccine
  • Intranasal immunization

Fingerprint

Dive into the research topics of 'Local SIgA response following administration of a novel intranasal inactivated influenza virus vaccine in community residing elderly'. Together they form a unique fingerprint.

Cite this