Abstract
Thiazolidinedione-8 (TZD-8) is an anti-quorum-sensing molecule that has the potential to effectively prevent catheter-associated urinary tract infections, a major healthcare challenge. Sustained-release drug-delivery systems can enhance drugs' therapeutic potential, by maintaining their therapeutic level and reducing their side effects. Varnishes for sustained release of TZD-8 based on ethylcellulose or ammonio methacrylate copolymer type A (Eudragit® RL) were developed. The main factors affecting release rate were found to be film thickness and presence of a hydrophilic or swellable polymer in the matrix. The release mechanism of ethylcellulose-based systems matched the Higuchi model. Selected varnishes were retained on catheters for at least 8 days. Sustained-release delivery systems of TZD-8 were active against Candida albicans biofilms. The present study demonstrates promising results en route to developing applications for the prevention of catheter-associated infections.
| Original language | English |
|---|---|
| Pages (from-to) | 164-170 |
| Number of pages | 7 |
| Journal | International Journal of Pharmaceutics |
| Volume | 485 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - 15 May 2015 |
Bibliographical note
Publisher Copyright:© 2015 Elsevier B.V. All rights reserved.
Keywords
- Catheter-associated infections
- Modeling
- Quorum sensing
- Sustained release
- Thiazolidinedione-8
- Varnish