TY - JOUR
T1 - Localization of the glutamate transporter GLT-1 in rat and macaque monkey retinae
AU - Rauen, Thomas
AU - Kanner, Baruch I.
PY - 1994/3/14
Y1 - 1994/3/14
N2 - Antibodies directed against a glutamate transporter (GLT-1) purified from rat brain were applied to cryostat sections of rat and macaque monkey retinae. In the brain, GLT-1 expression is found mainly in astrocytes, and therefore it has been suggested that GLT-1 may be a glutamate transporter specific to glial cells. However, in the rat retina, cones and two distinct cone bipolar cell types were strongly immunoreactive. In the monkey retina, flat midget bipolars and one diffuse bipolar cell type (DB2)), were found to be labelled. Müller cells or astrocytes, the neuroglial cells of rat and monkey retinae, were not GLT-1-immunoreactive.
AB - Antibodies directed against a glutamate transporter (GLT-1) purified from rat brain were applied to cryostat sections of rat and macaque monkey retinae. In the brain, GLT-1 expression is found mainly in astrocytes, and therefore it has been suggested that GLT-1 may be a glutamate transporter specific to glial cells. However, in the rat retina, cones and two distinct cone bipolar cell types were strongly immunoreactive. In the monkey retina, flat midget bipolars and one diffuse bipolar cell type (DB2)), were found to be labelled. Müller cells or astrocytes, the neuroglial cells of rat and monkey retinae, were not GLT-1-immunoreactive.
KW - Bipolar cell
KW - Cone
KW - Glutamate transporter
KW - Immunocytochemical localization
KW - Mammalian retina
UR - http://www.scopus.com/inward/record.url?scp=0028176067&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(94)90375-1
DO - 10.1016/0304-3940(94)90375-1
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C2 - 8047270
AN - SCOPUS:0028176067
SN - 0304-3940
VL - 169
SP - 137
EP - 140
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1-2
ER -