TY - JOUR
T1 - Logic gates and elementary computing by enzymes
AU - Baron, Ronan
AU - Lioubashevski, Oleg
AU - Katz, Eugenii
AU - Niazov, Tamara
AU - Willner, Itamar
PY - 2006/7/13
Y1 - 2006/7/13
N2 - Different selected enzymes, glucose oxidase (GOx), catalase (Cat), glucose dehydrogenase (GDH), horseradish peroxidase (HRP), and formaldehyde dehydrogenase (FDH), are used alone or coupled to construct eight different logic gates. The added substrates for the respective enzymes, glucose and H 2O2, act as the gate inputs, while the biocatalytically generated gluconic acid or NADH are the output signals that follow the operation of the gates. Different enzyme-based gates are XOR, INHIBIT A, INHIBIT B, AND, OR, NOR, Identity and Inverter gates. By combining the AND and XOR or the XOR and INHIBIT A gates, the half-adder and half-subtractor are constructed, respectively, opening the way to elementary computing by the use of enzymes.
AB - Different selected enzymes, glucose oxidase (GOx), catalase (Cat), glucose dehydrogenase (GDH), horseradish peroxidase (HRP), and formaldehyde dehydrogenase (FDH), are used alone or coupled to construct eight different logic gates. The added substrates for the respective enzymes, glucose and H 2O2, act as the gate inputs, while the biocatalytically generated gluconic acid or NADH are the output signals that follow the operation of the gates. Different enzyme-based gates are XOR, INHIBIT A, INHIBIT B, AND, OR, NOR, Identity and Inverter gates. By combining the AND and XOR or the XOR and INHIBIT A gates, the half-adder and half-subtractor are constructed, respectively, opening the way to elementary computing by the use of enzymes.
UR - http://www.scopus.com/inward/record.url?scp=33746345883&partnerID=8YFLogxK
U2 - 10.1021/jp0568327
DO - 10.1021/jp0568327
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C2 - 16821840
AN - SCOPUS:33746345883
SN - 1089-5639
VL - 110
SP - 8548
EP - 8553
JO - Journal of Physical Chemistry A
JF - Journal of Physical Chemistry A
IS - 27
ER -