Logic gates and elementary computing by enzymes

Ronan Baron, Oleg Lioubashevski, Eugenii Katz, Tamara Niazov, Itamar Willner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

170 Scopus citations

Abstract

Different selected enzymes, glucose oxidase (GOx), catalase (Cat), glucose dehydrogenase (GDH), horseradish peroxidase (HRP), and formaldehyde dehydrogenase (FDH), are used alone or coupled to construct eight different logic gates. The added substrates for the respective enzymes, glucose and H 2O2, act as the gate inputs, while the biocatalytically generated gluconic acid or NADH are the output signals that follow the operation of the gates. Different enzyme-based gates are XOR, INHIBIT A, INHIBIT B, AND, OR, NOR, Identity and Inverter gates. By combining the AND and XOR or the XOR and INHIBIT A gates, the half-adder and half-subtractor are constructed, respectively, opening the way to elementary computing by the use of enzymes.

Original languageEnglish
Pages (from-to)8548-8553
Number of pages6
JournalJournal of Physical Chemistry A
Volume110
Issue number27
DOIs
StatePublished - 13 Jul 2006

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