Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation

Tomohisa Toda; Tracy A Bedrosian; Simon T Schafer; Michael S Cuoco; Sara B Linker; Saeed Ghassemzadeh; Lisa Mitchell; Jack T Whiteley; Nicole Novaresi; Aidan H McDonald; Iryna S Gallina; Hyojung Yoon; Mark E Hester; Monique Pena; Christina Lim; Emelia Suljic; Abed AlFatah Mansour; Matthieu Boulard; Sarah L Parylak; Fred H Gage

doi:10.1016/j.celrep.2024.113774

Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation

Tomohisa Toda, Tracy A Bedrosian, Simon T Schafer, Michael S Cuoco, Sara B Linker, Saeed Ghassemzadeh, Lisa Mitchell, Jack T Whiteley, Nicole Novaresi, Aidan H McDonald, Iryna S Gallina, Hyojung Yoon, Mark E Hester, Monique Pena, Christina Lim, Emelia Suljic, Abed AlFatah Mansour, Matthieu Boulard, Sarah L Parylak, Fred H Gage

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Long interspersed nuclear element-1 (L1 or LINE-1) is a highly abundant mobile genetic element in both humans and mice, comprising almost 20% of each genome. L1s are silenced by several mechanisms, as their uncontrolled expression has the potential to induce genomic instability. However, L1s are paradoxically expressed at high levels in differentiating neural progenitor cells. Using in vitro and in vivo techniques to modulate L1 expression, we report that L1s play a critical role in both human and mouse brain development by regulating the rate of neural differentiation in a reverse-transcription-independent manner.

Original language	English
Article number	113774
Pages (from-to)	113774
Journal	Cell Reports
Volume	43
Issue number	2
DOIs	https://doi.org/10.1016/j.celrep.2024.113774
State	Published - 27 Feb 2024
Externally published	Yes

Bibliographical note

Keywords

Humans
Animals
Mice
Cell Differentiation
Genomic Instability
Long Interspersed Nucleotide Elements
Neural Stem Cells

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10.1016/j.celrep.2024.113774

http://www.cell.com/article/S2211124724001025/pdfLicense: CC BY-NC-ND

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Toda, T., Bedrosian, T. A., Schafer, S. T., Cuoco, M. S., Linker, S. B., Ghassemzadeh, S., Mitchell, L., Whiteley, J. T., Novaresi, N., McDonald, A. H., Gallina, I. S., Yoon, H., Hester, M. E., Pena, M., Lim, C., Suljic, E., AlFatah Mansour, A., Boulard, M., Parylak, S. L., & Gage, F. H. (2024). Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation. Cell Reports, 43(2), 113774. Article 113774. https://doi.org/10.1016/j.celrep.2024.113774

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abstract = "Long interspersed nuclear element-1 (L1 or LINE-1) is a highly abundant mobile genetic element in both humans and mice, comprising almost 20\% of each genome. L1s are silenced by several mechanisms, as their uncontrolled expression has the potential to induce genomic instability. However, L1s are paradoxically expressed at high levels in differentiating neural progenitor cells. Using in vitro and in vivo techniques to modulate L1 expression, we report that L1s play a critical role in both human and mouse brain development by regulating the rate of neural differentiation in a reverse-transcription-independent manner.",

keywords = "Humans, Animals, Mice, Cell Differentiation, Genomic Instability, Long Interspersed Nucleotide Elements, Neural Stem Cells",

author = "Tomohisa Toda and Bedrosian, \{Tracy A\} and Schafer, \{Simon T\} and Cuoco, \{Michael S\} and Linker, \{Sara B\} and Saeed Ghassemzadeh and Lisa Mitchell and Whiteley, \{Jack T\} and Nicole Novaresi and McDonald, \{Aidan H\} and Gallina, \{Iryna S\} and Hyojung Yoon and Hester, \{Mark E\} and Monique Pena and Christina Lim and Emelia Suljic and \{AlFatah Mansour\}, Abed and Matthieu Boulard and Parylak, \{Sarah L\} and Gage, \{Fred H\}",

year = "2024",

month = feb,

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doi = "10.1016/j.celrep.2024.113774",

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Toda, T, Bedrosian, TA, Schafer, ST, Cuoco, MS, Linker, SB, Ghassemzadeh, S, Mitchell, L, Whiteley, JT, Novaresi, N, McDonald, AH, Gallina, IS, Yoon, H, Hester, ME, Pena, M, Lim, C, Suljic, E, AlFatah Mansour, A, Boulard, M, Parylak, SL & Gage, FH 2024, 'Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation', Cell Reports, vol. 43, no. 2, 113774, pp. 113774. https://doi.org/10.1016/j.celrep.2024.113774

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AU - Toda, Tomohisa

AU - Bedrosian, Tracy A

AU - Schafer, Simon T

AU - Cuoco, Michael S

AU - Linker, Sara B

AU - Ghassemzadeh, Saeed

AU - Mitchell, Lisa

AU - Whiteley, Jack T

AU - Novaresi, Nicole

AU - McDonald, Aidan H

AU - Gallina, Iryna S

AU - Yoon, Hyojung

AU - Hester, Mark E

AU - Pena, Monique

AU - Lim, Christina

AU - Suljic, Emelia

AU - AlFatah Mansour, Abed

AU - Boulard, Matthieu

AU - Parylak, Sarah L

AU - Gage, Fred H

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AB - Long interspersed nuclear element-1 (L1 or LINE-1) is a highly abundant mobile genetic element in both humans and mice, comprising almost 20% of each genome. L1s are silenced by several mechanisms, as their uncontrolled expression has the potential to induce genomic instability. However, L1s are paradoxically expressed at high levels in differentiating neural progenitor cells. Using in vitro and in vivo techniques to modulate L1 expression, we report that L1s play a critical role in both human and mouse brain development by regulating the rate of neural differentiation in a reverse-transcription-independent manner.

KW - Humans

KW - Animals

KW - Mice

KW - Cell Differentiation

KW - Genomic Instability

KW - Long Interspersed Nucleotide Elements

KW - Neural Stem Cells

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Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation

Abstract

Bibliographical note

Keywords

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