Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a Sexually Dimorphic Manner

Manon Bohic; Irène Marics; Catarina Santos; Pascale Malapert; Nissim Ben-Arie; Chiara Salio; Ana Reynders; Yves Le Feuvre; Andrew J. Saurin; Aziz Moqrich

doi:10.1016/j.celrep.2019.12.041

Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a Sexually Dimorphic Manner

Manon Bohic, Irène Marics, Catarina Santos, Pascale Malapert, Nissim Ben-Arie, Chiara Salio, Ana Reynders, Yves Le Feuvre, Andrew J. Saurin, Aziz Moqrich^*

^*Corresponding author for this work

Department of Cell and Developmental Biology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Bohic et al. demonstrate that mice lacking the transcription factor BHLHA9 exhibit impaired thermotaxis and formalin-evoked pain. BHLHA9 mediates these effects by modulating spinal GABAergic signaling. The data consolidate the role of C-LTRMs in pain sensation and provide in vivo evidence of C-LTRMs in the discriminative aspects of temperature sensation.

Original language	American English
Pages (from-to)	602-610.e6
Journal	Cell Reports
Volume	30
Issue number	3
DOIs	https://doi.org/10.1016/j.celrep.2019.12.041
State	Published - 21 Jan 2020

Bibliographical note

Funding Information:
We are grateful to the Moqrich lab members for fruitful scientific discussions. This work has been funded by the European Research Council ( ERC ) starting grant paineurons 260435 and the Agence Nationale de la Recherche (ANR) Myochronic to A.M. M.B.’s PhD thesis was funded by the Ministère de l’éducation nationale et de la recherche and la Fondation pour la recherche médicale ( FRM ). N.B.-A was supported by the Israel Science Foundation (1051/15).

Publisher Copyright:
© 2019 The Author(s)

Keywords

Bhhlha9
C-LTMRs
ionotropic GABAergic signaling
sexual dimorphism

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10.1016/j.celrep.2019.12.041

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title = "Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a Sexually Dimorphic Manner",

abstract = "Bohic et al. demonstrate that mice lacking the transcription factor BHLHA9 exhibit impaired thermotaxis and formalin-evoked pain. BHLHA9 mediates these effects by modulating spinal GABAergic signaling. The data consolidate the role of C-LTRMs in pain sensation and provide in vivo evidence of C-LTRMs in the discriminative aspects of temperature sensation.",

keywords = "Bhhlha9, C-LTMRs, ionotropic GABAergic signaling, sexual dimorphism",

author = "Manon Bohic and Ir{\`e}ne Marics and Catarina Santos and Pascale Malapert and Nissim Ben-Arie and Chiara Salio and Ana Reynders and {Le Feuvre}, Yves and Saurin, {Andrew J.} and Aziz Moqrich",

note = "Funding Information: We are grateful to the Moqrich lab members for fruitful scientific discussions. This work has been funded by the European Research Council ( ERC ) starting grant paineurons 260435 and the Agence Nationale de la Recherche (ANR) Myochronic to A.M. M.B.{\textquoteright}s PhD thesis was funded by the Minist{\`e}re de l{\textquoteright}{\'e}ducation nationale et de la recherche and la Fondation pour la recherche m{\'e}dicale ( FRM ). N.B.-A was supported by the Israel Science Foundation (1051/15). Publisher Copyright: {\textcopyright} 2019 The Author(s)",

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doi = "10.1016/j.celrep.2019.12.041",

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AU - Bohic, Manon

AU - Marics, Irène

AU - Santos, Catarina

AU - Malapert, Pascale

AU - Ben-Arie, Nissim

AU - Salio, Chiara

AU - Reynders, Ana

AU - Le Feuvre, Yves

AU - Saurin, Andrew J.

AU - Moqrich, Aziz

N1 - Funding Information: We are grateful to the Moqrich lab members for fruitful scientific discussions. This work has been funded by the European Research Council ( ERC ) starting grant paineurons 260435 and the Agence Nationale de la Recherche (ANR) Myochronic to A.M. M.B.’s PhD thesis was funded by the Ministère de l’éducation nationale et de la recherche and la Fondation pour la recherche médicale ( FRM ). N.B.-A was supported by the Israel Science Foundation (1051/15). Publisher Copyright: © 2019 The Author(s)

PY - 2020/1/21

Y1 - 2020/1/21

N2 - Bohic et al. demonstrate that mice lacking the transcription factor BHLHA9 exhibit impaired thermotaxis and formalin-evoked pain. BHLHA9 mediates these effects by modulating spinal GABAergic signaling. The data consolidate the role of C-LTRMs in pain sensation and provide in vivo evidence of C-LTRMs in the discriminative aspects of temperature sensation.

AB - Bohic et al. demonstrate that mice lacking the transcription factor BHLHA9 exhibit impaired thermotaxis and formalin-evoked pain. BHLHA9 mediates these effects by modulating spinal GABAergic signaling. The data consolidate the role of C-LTRMs in pain sensation and provide in vivo evidence of C-LTRMs in the discriminative aspects of temperature sensation.

KW - Bhhlha9

KW - C-LTMRs

KW - ionotropic GABAergic signaling

KW - sexual dimorphism

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DO - 10.1016/j.celrep.2019.12.041

M3 - Article

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AN - SCOPUS:85077988576

SN - 2211-1247

VL - 30

SP - 602-610.e6

JO - Cell Reports

JF - Cell Reports

IS - 3

ER -

Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a Sexually Dimorphic Manner

Abstract

Bibliographical note

Keywords

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