Bohic et al. demonstrate that mice lacking the transcription factor BHLHA9 exhibit impaired thermotaxis and formalin-evoked pain. BHLHA9 mediates these effects by modulating spinal GABAergic signaling. The data consolidate the role of C-LTRMs in pain sensation and provide in vivo evidence of C-LTRMs in the discriminative aspects of temperature sensation.
Bibliographical noteFunding Information:
We are grateful to the Moqrich lab members for fruitful scientific discussions. This work has been funded by the European Research Council ( ERC ) starting grant paineurons 260435 and the Agence Nationale de la Recherche (ANR) Myochronic to A.M. M.B.’s PhD thesis was funded by the Ministère de l’éducation nationale et de la recherche and la Fondation pour la recherche médicale ( FRM ). N.B.-A was supported by the Israel Science Foundation (1051/15).
© 2019 The Author(s)
- ionotropic GABAergic signaling
- sexual dimorphism