Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a Sexually Dimorphic Manner

Manon Bohic; Irène Marics; Catarina Santos; Pascale Malapert; Nissim Ben-Arie; Chiara Salio; Ana Reynders; Yves Le Feuvre; Andrew J. Saurin; Aziz Moqrich

doi:10.1016/j.celrep.2019.12.041

Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a Sexually Dimorphic Manner

Manon Bohic, Irène Marics, Catarina Santos, Pascale Malapert, Nissim Ben-Arie, Chiara Salio, Ana Reynders, Yves Le Feuvre, Andrew J. Saurin, Aziz Moqrich^*

^*Corresponding author for this work

Department of Cell and Developmental Biology

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Bohic et al. demonstrate that mice lacking the transcription factor BHLHA9 exhibit impaired thermotaxis and formalin-evoked pain. BHLHA9 mediates these effects by modulating spinal GABAergic signaling. The data consolidate the role of C-LTRMs in pain sensation and provide in vivo evidence of C-LTRMs in the discriminative aspects of temperature sensation.

Original language	English
Pages (from-to)	602-610.e6
Journal	Cell Reports
Volume	30
Issue number	3
DOIs	https://doi.org/10.1016/j.celrep.2019.12.041
State	Published - 21 Jan 2020

Bibliographical note

Publisher Copyright:
© 2019 The Author(s)

Keywords

Bhhlha9
C-LTMRs
ionotropic GABAergic signaling
sexual dimorphism

Access to Document

10.1016/j.celrep.2019.12.041

Cite this

@article{015940729b844c548fc3c5b6e4aeacbe,

title = "Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a Sexually Dimorphic Manner",

abstract = "Bohic et al. demonstrate that mice lacking the transcription factor BHLHA9 exhibit impaired thermotaxis and formalin-evoked pain. BHLHA9 mediates these effects by modulating spinal GABAergic signaling. The data consolidate the role of C-LTRMs in pain sensation and provide in vivo evidence of C-LTRMs in the discriminative aspects of temperature sensation.",

keywords = "Bhhlha9, C-LTMRs, ionotropic GABAergic signaling, sexual dimorphism",

author = "Manon Bohic and Ir{\`e}ne Marics and Catarina Santos and Pascale Malapert and Nissim Ben-Arie and Chiara Salio and Ana Reynders and {Le Feuvre}, Yves and Saurin, {Andrew J.} and Aziz Moqrich",

note = "Publisher Copyright: {\textcopyright} 2019 The Author(s)",

year = "2020",

month = jan,

day = "21",

doi = "10.1016/j.celrep.2019.12.041",

language = "אנגלית",

volume = "30",

pages = "602--610.e6",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Cell Press",

number = "3",

}

TY - JOUR

T1 - Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a Sexually Dimorphic Manner

AU - Bohic, Manon

AU - Marics, Irène

AU - Santos, Catarina

AU - Malapert, Pascale

AU - Ben-Arie, Nissim

AU - Salio, Chiara

AU - Reynders, Ana

AU - Le Feuvre, Yves

AU - Saurin, Andrew J.

AU - Moqrich, Aziz

PY - 2020/1/21

Y1 - 2020/1/21

N2 - Bohic et al. demonstrate that mice lacking the transcription factor BHLHA9 exhibit impaired thermotaxis and formalin-evoked pain. BHLHA9 mediates these effects by modulating spinal GABAergic signaling. The data consolidate the role of C-LTRMs in pain sensation and provide in vivo evidence of C-LTRMs in the discriminative aspects of temperature sensation.

AB - Bohic et al. demonstrate that mice lacking the transcription factor BHLHA9 exhibit impaired thermotaxis and formalin-evoked pain. BHLHA9 mediates these effects by modulating spinal GABAergic signaling. The data consolidate the role of C-LTRMs in pain sensation and provide in vivo evidence of C-LTRMs in the discriminative aspects of temperature sensation.

KW - Bhhlha9

KW - C-LTMRs

KW - ionotropic GABAergic signaling

KW - sexual dimorphism

UR - http://www.scopus.com/inward/record.url?scp=85077988576&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2019.12.041

DO - 10.1016/j.celrep.2019.12.041

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 31968239

AN - SCOPUS:85077988576

SN - 2211-1247

VL - 30

SP - 602-610.e6

JO - Cell Reports

JF - Cell Reports

IS - 3

ER -

Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a Sexually Dimorphic Manner

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this