Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a Sexually Dimorphic Manner

Manon Bohic, Irène Marics, Catarina Santos, Pascale Malapert, Nissim Ben-Arie, Chiara Salio, Ana Reynders, Yves Le Feuvre, Andrew J. Saurin, Aziz Moqrich*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Bohic et al. demonstrate that mice lacking the transcription factor BHLHA9 exhibit impaired thermotaxis and formalin-evoked pain. BHLHA9 mediates these effects by modulating spinal GABAergic signaling. The data consolidate the role of C-LTRMs in pain sensation and provide in vivo evidence of C-LTRMs in the discriminative aspects of temperature sensation.

Original languageAmerican English
Pages (from-to)602-610.e6
JournalCell Reports
Volume30
Issue number3
DOIs
StatePublished - 21 Jan 2020

Bibliographical note

Publisher Copyright:
© 2019 The Author(s)

Keywords

  • Bhhlha9
  • C-LTMRs
  • ionotropic GABAergic signaling
  • sexual dimorphism

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