Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a Sexually Dimorphic Manner

Manon Bohic, Irène Marics, Catarina Santos, Pascale Malapert, Nissim Ben-Arie, Chiara Salio, Ana Reynders, Yves Le Feuvre, Andrew J. Saurin, Aziz Moqrich*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Bohic et al. demonstrate that mice lacking the transcription factor BHLHA9 exhibit impaired thermotaxis and formalin-evoked pain. BHLHA9 mediates these effects by modulating spinal GABAergic signaling. The data consolidate the role of C-LTRMs in pain sensation and provide in vivo evidence of C-LTRMs in the discriminative aspects of temperature sensation.

Original languageAmerican English
Pages (from-to)602-610.e6
JournalCell Reports
Issue number3
StatePublished - 21 Jan 2020

Bibliographical note

Funding Information:
We are grateful to the Moqrich lab members for fruitful scientific discussions. This work has been funded by the European Research Council ( ERC ) starting grant paineurons 260435 and the Agence Nationale de la Recherche (ANR) Myochronic to A.M. M.B.’s PhD thesis was funded by the Ministère de l’éducation nationale et de la recherche and la Fondation pour la recherche médicale ( FRM ). N.B.-A was supported by the Israel Science Foundation (1051/15).

Publisher Copyright:
© 2019 The Author(s)


  • Bhhlha9
  • C-LTMRs
  • ionotropic GABAergic signaling
  • sexual dimorphism


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