Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a Sexually Dimorphic Manner

Manon Bohic; Irène Marics; Catarina Santos; Pascale Malapert; Nissim Ben-Arie; Chiara Salio; Ana Reynders; Yves Le Feuvre; Andrew J. Saurin; Aziz Moqrich

doi:10.1016/j.celrep.2019.12.041

Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a Sexually Dimorphic Manner

Manon Bohic
, Irène Marics
, Catarina Santos
, Pascale Malapert
, Nissim Ben-Arie
, Chiara Salio
, Ana Reynders
, Yves Le Feuvre
, Andrew J. Saurin
, Aziz Moqrich^*

^*Corresponding author for this work

Department of Cell and Developmental Biology

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Bohic et al. demonstrate that mice lacking the transcription factor BHLHA9 exhibit impaired thermotaxis and formalin-evoked pain. BHLHA9 mediates these effects by modulating spinal GABAergic signaling. The data consolidate the role of C-LTRMs in pain sensation and provide in vivo evidence of C-LTRMs in the discriminative aspects of temperature sensation.

Original language	English
Pages (from-to)	602-610.e6
Journal	Cell Reports
Volume	30
Issue number	3
DOIs	https://doi.org/10.1016/j.celrep.2019.12.041
State	Published - 21 Jan 2020

Bibliographical note

Publisher Copyright:
© 2019 The Author(s)

Keywords

Bhhlha9
C-LTMRs
ionotropic GABAergic signaling
sexual dimorphism

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10.1016/j.celrep.2019.12.041

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title = "Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a Sexually Dimorphic Manner",

abstract = "Bohic et al. demonstrate that mice lacking the transcription factor BHLHA9 exhibit impaired thermotaxis and formalin-evoked pain. BHLHA9 mediates these effects by modulating spinal GABAergic signaling. The data consolidate the role of C-LTRMs in pain sensation and provide in vivo evidence of C-LTRMs in the discriminative aspects of temperature sensation.",

keywords = "Bhhlha9, C-LTMRs, ionotropic GABAergic signaling, sexual dimorphism",

author = "Manon Bohic and Ir{\`e}ne Marics and Catarina Santos and Pascale Malapert and Nissim Ben-Arie and Chiara Salio and Ana Reynders and \{Le Feuvre\}, Yves and Saurin, \{Andrew J.\} and Aziz Moqrich",

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doi = "10.1016/j.celrep.2019.12.041",

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T1 - Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a Sexually Dimorphic Manner

AU - Bohic, Manon

AU - Marics, Irène

AU - Santos, Catarina

AU - Malapert, Pascale

AU - Ben-Arie, Nissim

AU - Salio, Chiara

AU - Reynders, Ana

AU - Le Feuvre, Yves

AU - Saurin, Andrew J.

AU - Moqrich, Aziz

PY - 2020/1/21

Y1 - 2020/1/21

N2 - Bohic et al. demonstrate that mice lacking the transcription factor BHLHA9 exhibit impaired thermotaxis and formalin-evoked pain. BHLHA9 mediates these effects by modulating spinal GABAergic signaling. The data consolidate the role of C-LTRMs in pain sensation and provide in vivo evidence of C-LTRMs in the discriminative aspects of temperature sensation.

AB - Bohic et al. demonstrate that mice lacking the transcription factor BHLHA9 exhibit impaired thermotaxis and formalin-evoked pain. BHLHA9 mediates these effects by modulating spinal GABAergic signaling. The data consolidate the role of C-LTRMs in pain sensation and provide in vivo evidence of C-LTRMs in the discriminative aspects of temperature sensation.

KW - Bhhlha9

KW - C-LTMRs

KW - ionotropic GABAergic signaling

KW - sexual dimorphism

UR - https://www.scopus.com/pages/publications/85077988576

U2 - 10.1016/j.celrep.2019.12.041

DO - 10.1016/j.celrep.2019.12.041

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AN - SCOPUS:85077988576

SN - 2211-1247

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SP - 602-610.e6

JO - Cell Reports

JF - Cell Reports

IS - 3

ER -

Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a Sexually Dimorphic Manner

Abstract

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Keywords

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