TY - JOUR
T1 - Low-carbohydrate diet proved effective and safe for youths with type 1 diabetes
T2 - A randomised trial
AU - Levran, Neriya
AU - Levek, Noah
AU - Gruber, Noah
AU - Afek, Arnon
AU - Monsonego-Ornan, Efrat
AU - Pinhas-Hamiel, Orit
N1 - Publisher Copyright:
© 2024 The Author(s). Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.
PY - 2024
Y1 - 2024
N2 - Aim: Low-carbohydrate (LC) diets have gained popularity. We compared glycaemic and metabolic parameters following an LC versus a Mediterranean (MED) diet in adolescents and youths with type 1 diabetes. Methods: In a six-month, open-label, randomised trial, 40 individuals were assigned to either diet. Glycaemic outcomes, based on continuous glucose monitoring, included per cent time of blood glucose in the range [3.9–10.0 mmol/L (70–180 mg/dL)] and haemoglobin A1c (HbA1c). Results: Twenty-eight (70%) were females. The median age was 18 years. After 6 months, the median time in range increased from 47% to 58% in the LC and from 52% to 64% in the MED diet group (p = 0.98). The delta values for the time in range were 16% and 7% for the respective groups (p = 0.09). The percentage of time >13.9 mmol/L (>250 mg/dL) improved more in the LC diet than in the MED diet group: −10% vs. −2% (p = 0.005). The percentage of time <3.0 mmol/L (<54 mg/dL) was comparable. The delta HbA1c improved in both groups: −0.7% vs. −0.1% (p = 0.02). Changes in BMI Z-score and lipid levels were similar. Conclusion: Both diets improved glycaemic outcomes in adolescents and youths with type 1 diabetes, without increasing hypoglycaemia or cardiovascular risk factors, indicating comparable safety and efficacy.
AB - Aim: Low-carbohydrate (LC) diets have gained popularity. We compared glycaemic and metabolic parameters following an LC versus a Mediterranean (MED) diet in adolescents and youths with type 1 diabetes. Methods: In a six-month, open-label, randomised trial, 40 individuals were assigned to either diet. Glycaemic outcomes, based on continuous glucose monitoring, included per cent time of blood glucose in the range [3.9–10.0 mmol/L (70–180 mg/dL)] and haemoglobin A1c (HbA1c). Results: Twenty-eight (70%) were females. The median age was 18 years. After 6 months, the median time in range increased from 47% to 58% in the LC and from 52% to 64% in the MED diet group (p = 0.98). The delta values for the time in range were 16% and 7% for the respective groups (p = 0.09). The percentage of time >13.9 mmol/L (>250 mg/dL) improved more in the LC diet than in the MED diet group: −10% vs. −2% (p = 0.005). The percentage of time <3.0 mmol/L (<54 mg/dL) was comparable. The delta HbA1c improved in both groups: −0.7% vs. −0.1% (p = 0.02). Changes in BMI Z-score and lipid levels were similar. Conclusion: Both diets improved glycaemic outcomes in adolescents and youths with type 1 diabetes, without increasing hypoglycaemia or cardiovascular risk factors, indicating comparable safety and efficacy.
KW - low-carbohydrate diet
KW - mediterranean diet
KW - time in range
KW - type 1 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85206695937&partnerID=8YFLogxK
U2 - 10.1111/apa.17455
DO - 10.1111/apa.17455
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C2 - 39412084
AN - SCOPUS:85206695937
SN - 0803-5253
JO - Acta Paediatrica, International Journal of Paediatrics
JF - Acta Paediatrica, International Journal of Paediatrics
ER -