Low molecular weight RNAs of Moloney murine leukemia virus: identification of the primer for RNA directed DNA synthesis

G. Peters; F. Harada; J. E. Dahlberg; A. Panet; W. A. Haseltine; D. Baltimore

doi:10.1128/jvi.21.3.1031-1041.1977

Low molecular weight RNAs of Moloney murine leukemia virus: identification of the primer for RNA directed DNA synthesis

G. Peters, F. Harada, J. E. Dahlberg, A. Panet, W. A. Haseltine, D. Baltimore

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

101 Scopus citations

Abstract

The small RNAs of Moloney murine leukemia virus (M MuLV) were fractionated into at least 15 species by two dimensional polyacrylamide gel electrophoresis. The pattern of small RNAs is significantly different from that of Rous sarcoma virus. A subset of the virion small RNAs is associated with the genome RNA in the 70S complex. One of the associated molecules, a cellular tRNA, is tightly bound to the genome RNA and serves as the major primer for M MuLV RNA directed DNA synthesis in vitro.

Original language	English
Pages (from-to)	1031-1041
Number of pages	11
Journal	Unknown Journal
Volume	21
Issue number	3
DOIs	https://doi.org/10.1128/jvi.21.3.1031-1041.1977
State	Published - 1 Mar 1977

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10.1128/jvi.21.3.1031-1041.1977

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Low molecular weight RNAs of Moloney murine leukemia virus: identification of the primer for RNA directed DNA synthesis

Abstract

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