Abstract
In slices of parietal neocortex, evidence was obtained for the existence of a low-threshold Ca2+ conductance in most neurons. This conductance became apparent when resting membrane potential was held below -60 mV by continuously injected, depolarizing current. Under these conditions, brief hyperpolarizing pulses were followed by generation of tetrodotoxin (TTX)-resistent, Mn2+-sensitive, low-threshold spikes. The results suggest that in neocortex, as in many subcortical structures, low-threshold Ca current may be responsible for burst generation in some neurons.
Original language | English |
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Pages (from-to) | 117-122 |
Number of pages | 6 |
Journal | Neuroscience Letters |
Volume | 81 |
Issue number | 1-2 |
DOIs | |
State | Published - 16 Oct 1987 |
Externally published | Yes |
Keywords
- Brain slice
- Calcium current
- Low-threshold spike
- Neocortex