Low-threshold calcium electrogenesis in neocortical neurons

A. Friedman, M. J. Gutnick*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

In slices of parietal neocortex, evidence was obtained for the existence of a low-threshold Ca2+ conductance in most neurons. This conductance became apparent when resting membrane potential was held below -60 mV by continuously injected, depolarizing current. Under these conditions, brief hyperpolarizing pulses were followed by generation of tetrodotoxin (TTX)-resistent, Mn2+-sensitive, low-threshold spikes. The results suggest that in neocortex, as in many subcortical structures, low-threshold Ca current may be responsible for burst generation in some neurons.

Original languageEnglish
Pages (from-to)117-122
Number of pages6
JournalNeuroscience Letters
Volume81
Issue number1-2
DOIs
StatePublished - 16 Oct 1987
Externally publishedYes

Keywords

  • Brain slice
  • Calcium current
  • Low-threshold spike
  • Neocortex

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