TY - JOUR
T1 - Lymphocyte subpopulations in chronic active hepatitis
T2 - Increase in lymphocytes forming stable E-rosettes
AU - Galili, U.
AU - Eliakim, M.
AU - Slavin, S.
AU - Schlesinger, M.
PY - 1975/11
Y1 - 1975/11
N2 - The proportion of blood lymphocytes forming rosettes either with sheep red blood cells (E-rosettes) or with red blood cells coated with antibody and complement (EAC′-rosettes) was determined in patients with chronic active hepatitis (CAH). There was no significant difference in the relative proportion of these cells in 13 untreated patients, 6 treated patients, 5 patients in remission, and 6 patients with acute hepatitis, when compared with normal controls. From 7 to 32% (mean 18.0%) of lymphocytes from patients with untreated CAH formed E-rosettes that did not disintegrate following incubation at 37°C for half an hour (stable E-rosettes). The percentage of lymphocytes forming stable E-rosettes in all other groups of patients and in healthy subjects varied between 0 and 3. Following cortisone therapy, the proportion of lymphocytes forming stable E-rosettes dropped promptly. Stable E-rosettes have not been described previously in relation to clinical disorders.
AB - The proportion of blood lymphocytes forming rosettes either with sheep red blood cells (E-rosettes) or with red blood cells coated with antibody and complement (EAC′-rosettes) was determined in patients with chronic active hepatitis (CAH). There was no significant difference in the relative proportion of these cells in 13 untreated patients, 6 treated patients, 5 patients in remission, and 6 patients with acute hepatitis, when compared with normal controls. From 7 to 32% (mean 18.0%) of lymphocytes from patients with untreated CAH formed E-rosettes that did not disintegrate following incubation at 37°C for half an hour (stable E-rosettes). The percentage of lymphocytes forming stable E-rosettes in all other groups of patients and in healthy subjects varied between 0 and 3. Following cortisone therapy, the proportion of lymphocytes forming stable E-rosettes dropped promptly. Stable E-rosettes have not been described previously in relation to clinical disorders.
UR - http://www.scopus.com/inward/record.url?scp=0016805355&partnerID=8YFLogxK
U2 - 10.1016/0090-1229(75)90095-1
DO - 10.1016/0090-1229(75)90095-1
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C2 - 1081936
AN - SCOPUS:0016805355
SN - 0090-1229
VL - 4
SP - 538
EP - 544
JO - Clinical Immunology and Immunopathology
JF - Clinical Immunology and Immunopathology
IS - 4
ER -
