Macrocyclization of a Ligand Targeting a Toxic RNA Dramatically Improves Potency

Keyphrases

• Toxic RNA 100%
• Ligand-targeted 100%
• Macrocyclization 100%
• Bioactivity 66%
• Small Molecules 33%
• MiRNA Target 33%
• Human Disease 33%
• Muscle Cells 33%
• RNA Molecules 33%
• Myotonic Dystrophy 33%
• Myotubes 33%
• RNA Function 33%
• Macrocycles 33%
• Trinucleotide Expansion 33%
• Patient-derived 33%
• Cell Permeability 33%
• Macrocyclic Compounds 33%
• Muscleblind-like 33%
• Toxic Interaction 33%
• Dimeric Ligands 33%
• Bioactive Ligands 33%

Chemistry

• Toxic 100%
• RNA 100%
• macrocyclization 100%
• Bioactivity 33%
• Macrocycle 16%
• Macrocyclic Compound 16%