TY - JOUR
T1 - Macromolecular Nano-Assemblies for Enhancing the Effect of Oxygen-Dependent Photodynamic Therapy Against Hypoxic Tumors
AU - Zhang, Peipei
AU - Cheng, Meng
AU - Levi-Kalisman, Yael
AU - Raviv, Uri
AU - Xu, Yichun
AU - Han, Junsong
AU - Dou, Hongjing
N1 - Publisher Copyright:
© 2024 Wiley-VCH GmbH.
PY - 2024/8/1
Y1 - 2024/8/1
N2 - In oxygen (O2)-dependent photodynamic therapy (PDT), photosensitizers absorb light energy, which is then transferred to ambient O2 and subsequently generates cytotoxic singlet oxygen (1O2). Therefore, the availability of O2 and the utilization efficiency of generated 1O2 are two significant factors that influence the effectiveness of PDT. However, tumor microenvironments (TMEs) characterized by hypoxia and limited utilization efficiency of 1O2 resulting from its short half-life and short diffusion distance significantly restrict the applicability of PDT for hypoxic tumors. To address these challenges, numerous macromolecular nano-assemblies (MNAs) have been designed to relieve hypoxia, utilize hypoxia or enhance the utilization efficiency of 1O2. Herein, we provide a comprehensive review on recent advancements achieved with MNAs in enhancing the effectiveness of O2-dependent PDT against hypoxic tumors.
AB - In oxygen (O2)-dependent photodynamic therapy (PDT), photosensitizers absorb light energy, which is then transferred to ambient O2 and subsequently generates cytotoxic singlet oxygen (1O2). Therefore, the availability of O2 and the utilization efficiency of generated 1O2 are two significant factors that influence the effectiveness of PDT. However, tumor microenvironments (TMEs) characterized by hypoxia and limited utilization efficiency of 1O2 resulting from its short half-life and short diffusion distance significantly restrict the applicability of PDT for hypoxic tumors. To address these challenges, numerous macromolecular nano-assemblies (MNAs) have been designed to relieve hypoxia, utilize hypoxia or enhance the utilization efficiency of 1O2. Herein, we provide a comprehensive review on recent advancements achieved with MNAs in enhancing the effectiveness of O2-dependent PDT against hypoxic tumors.
KW - Hypoxic tumors
KW - Macromolecule
KW - Nanostructures
KW - O-dependent photodynamic therapy
KW - Self-assembly
UR - http://www.scopus.com/inward/record.url?scp=85198044442&partnerID=8YFLogxK
U2 - 10.1002/chem.202401700
DO - 10.1002/chem.202401700
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???
C2 - 38797874
AN - SCOPUS:85198044442
SN - 0947-6539
VL - 30
JO - Chemistry - A European Journal
JF - Chemistry - A European Journal
IS - 43
M1 - e202401700
ER -
