Macrophage biology in the Anx-A1-/- mouse

S. Yona; Barbara Ward; Julia C. Buckingham; M. Perretti; R. J. Flower

doi:10.1016/j.plefa.2004.10.008

Macrophage biology in the Anx-A1^-/- mouse

S. Yona, Barbara Ward, Julia C. Buckingham, M. Perretti, R. J. Flower

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Historical data suggested that a soluble protein, since identified as annexin-A1 (Anx-A1) was released from macrophages following glucocorticoid stimulation and could modulate eicosanoid production and other functions of these cells. Here, we review some recent findings using a line of Anx-A1 ^-/- mice to explore the impact of Anx-A1 gene deletion on macrophage biology. The absence of Anx-A1 selectively alters phagocytic capacity of rodent resident peritoneal macrophages apparently through changes in surface adhesion molecule expression. Anx-A1 is also apparently important in the tonic down-regulation of other macrophage functions such as COX-2 induction, PGE ₂ release and the production of reactive oxygen species.

Original language	English
Pages (from-to)	95-103
Number of pages	9
Journal	Prostaglandins Leukotrienes and Essential Fatty Acids
Volume	72
Issue number	2 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.plefa.2004.10.008
State	Published - Feb 2005
Externally published	Yes

Bibliographical note

Funding Information:
RJF is a Principal Fellow of the Wellcome Trust, MP is a Senior Research Fellow of the Arthritis Research Campaign and SY holds a Ph.D. studentship from the Nuffield Foundation, UK. The authors wish to thank the Wellcome Trust (Grant no. 051887/97) and the Oliver Bird Fund (Project RHE/00057/G) for supporting this study.

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10.1016/j.plefa.2004.10.008

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title = "Macrophage biology in the Anx-A1-/- mouse",

abstract = "Historical data suggested that a soluble protein, since identified as annexin-A1 (Anx-A1) was released from macrophages following glucocorticoid stimulation and could modulate eicosanoid production and other functions of these cells. Here, we review some recent findings using a line of Anx-A1 -/- mice to explore the impact of Anx-A1 gene deletion on macrophage biology. The absence of Anx-A1 selectively alters phagocytic capacity of rodent resident peritoneal macrophages apparently through changes in surface adhesion molecule expression. Anx-A1 is also apparently important in the tonic down-regulation of other macrophage functions such as COX-2 induction, PGE 2 release and the production of reactive oxygen species.",

author = "S. Yona and Barbara Ward and Buckingham, {Julia C.} and M. Perretti and Flower, {R. J.}",

note = "Funding Information: RJF is a Principal Fellow of the Wellcome Trust, MP is a Senior Research Fellow of the Arthritis Research Campaign and SY holds a Ph.D. studentship from the Nuffield Foundation, UK. The authors wish to thank the Wellcome Trust (Grant no. 051887/97) and the Oliver Bird Fund (Project RHE/00057/G) for supporting this study. ",

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AU - Ward, Barbara

AU - Buckingham, Julia C.

AU - Perretti, M.

AU - Flower, R. J.

N1 - Funding Information: RJF is a Principal Fellow of the Wellcome Trust, MP is a Senior Research Fellow of the Arthritis Research Campaign and SY holds a Ph.D. studentship from the Nuffield Foundation, UK. The authors wish to thank the Wellcome Trust (Grant no. 051887/97) and the Oliver Bird Fund (Project RHE/00057/G) for supporting this study.

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AB - Historical data suggested that a soluble protein, since identified as annexin-A1 (Anx-A1) was released from macrophages following glucocorticoid stimulation and could modulate eicosanoid production and other functions of these cells. Here, we review some recent findings using a line of Anx-A1 -/- mice to explore the impact of Anx-A1 gene deletion on macrophage biology. The absence of Anx-A1 selectively alters phagocytic capacity of rodent resident peritoneal macrophages apparently through changes in surface adhesion molecule expression. Anx-A1 is also apparently important in the tonic down-regulation of other macrophage functions such as COX-2 induction, PGE 2 release and the production of reactive oxygen species.

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IS - 2 SPEC. ISS.

ER -

Macrophage biology in the Anx-A1^-/- mouse

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Bibliographical note

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