TY - JOUR
T1 - Macrophage functions in high and low cancer incidence strains of mice. A comparative study
AU - Gallily, R.
AU - Haran-Ghera, N.
PY - 1979
Y1 - 1979
N2 - Various functions of macrophage derived from different age groups of SJL/J mice, a high-cancer-incidence inbred strain, and BALB/c or C57B1/6 mice, two low-cancer-incidence strains, were studied and compared. SJL/J macrophages derived from 2-4 month-old mice were functionally hyperactive. The cells demonstrated elevated acid phosphatase levels and enhanced phagocytic, bacteriostatic, and cytotoxic activities when compared to BALB/c or C57B1/6 macrophages derived from mice of the same age. Bacteriostasis and two lysosomal enzyme activities were still potentiated in SJL/J macrophages derived from 12-17 month-old mice, compared to BALB/c mice, whereas macrophages from 12-17 month-old SJL/J mice, with or without tumors, demonstrated depressed macrophage-mediated cytotoxicity as well as a functional defect in their ability to handle Shigella antigen.
AB - Various functions of macrophage derived from different age groups of SJL/J mice, a high-cancer-incidence inbred strain, and BALB/c or C57B1/6 mice, two low-cancer-incidence strains, were studied and compared. SJL/J macrophages derived from 2-4 month-old mice were functionally hyperactive. The cells demonstrated elevated acid phosphatase levels and enhanced phagocytic, bacteriostatic, and cytotoxic activities when compared to BALB/c or C57B1/6 macrophages derived from mice of the same age. Bacteriostasis and two lysosomal enzyme activities were still potentiated in SJL/J macrophages derived from 12-17 month-old mice, compared to BALB/c mice, whereas macrophages from 12-17 month-old SJL/J mice, with or without tumors, demonstrated depressed macrophage-mediated cytotoxicity as well as a functional defect in their ability to handle Shigella antigen.
UR - http://www.scopus.com/inward/record.url?scp=0018477450&partnerID=8YFLogxK
U2 - 10.1016/S0145-305X(79)80047-6
DO - 10.1016/S0145-305X(79)80047-6
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C2 - 389688
AN - SCOPUS:0018477450
SN - 0145-305X
VL - 3
SP - 523
EP - 536
JO - Developmental and Comparative Immunology
JF - Developmental and Comparative Immunology
IS - C
ER -