Macrophage functions in high and low cancer incidence strains of mice. A comparative study

R. Gallily*, N. Haran-Ghera

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Various functions of macrophage derived from different age groups of SJL/J mice, a high-cancer-incidence inbred strain, and BALB/c or C57B1/6 mice, two low-cancer-incidence strains, were studied and compared. SJL/J macrophages derived from 2-4 month-old mice were functionally hyperactive. The cells demonstrated elevated acid phosphatase levels and enhanced phagocytic, bacteriostatic, and cytotoxic activities when compared to BALB/c or C57B1/6 macrophages derived from mice of the same age. Bacteriostasis and two lysosomal enzyme activities were still potentiated in SJL/J macrophages derived from 12-17 month-old mice, compared to BALB/c mice, whereas macrophages from 12-17 month-old SJL/J mice, with or without tumors, demonstrated depressed macrophage-mediated cytotoxicity as well as a functional defect in their ability to handle Shigella antigen.

Original languageEnglish
Pages (from-to)523-536
Number of pages14
JournalDevelopmental and Comparative Immunology
Volume3
Issue numberC
DOIs
StatePublished - 1979
Externally publishedYes

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