Magnetically amplified DNA assays (MADA): Sensing of viral DNA and single-base mis-matches by using nucleic acid modified magnetic particles

Fernando Patolsky; Yossi Weizmann; Eugenii Katz; Itamar Willner

doi:10.1002/anie.200250379

Magnetically amplified DNA assays (MADA): Sensing of viral DNA and single-base mis-matches by using nucleic acid modified magnetic particles

Fernando Patolsky
, Yossi Weizmann
, Eugenii Katz
, Itamar Willner^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

131 Scopus citations

Abstract

Taking DNA analysis for a spin: Amplified detection of viral DNA and single-base mutations in nucleic acids is accomplished by the thermally cycled incorporation of biotin labels into DNA replica associated with magnetic particles, by the electrocatalyzed biochemiluminescence transduction of the DNA recognition events, and by the rotation of the magnetic particles on electrode surfaces (see schematic representation).

Original language	English
Pages (from-to)	2372-2376
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	42
Issue number	21
DOIs	https://doi.org/10.1002/anie.200250379
State	Published - 30 May 2003

Keywords

Biosensors
Chemiluminescence
DNA
Magnetic particles

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10.1002/anie.200250379

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abstract = "Taking DNA analysis for a spin: Amplified detection of viral DNA and single-base mutations in nucleic acids is accomplished by the thermally cycled incorporation of biotin labels into DNA replica associated with magnetic particles, by the electrocatalyzed biochemiluminescence transduction of the DNA recognition events, and by the rotation of the magnetic particles on electrode surfaces (see schematic representation).",

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AU - Weizmann, Yossi

AU - Katz, Eugenii

AU - Willner, Itamar

PY - 2003/5/30

Y1 - 2003/5/30

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AB - Taking DNA analysis for a spin: Amplified detection of viral DNA and single-base mutations in nucleic acids is accomplished by the thermally cycled incorporation of biotin labels into DNA replica associated with magnetic particles, by the electrocatalyzed biochemiluminescence transduction of the DNA recognition events, and by the rotation of the magnetic particles on electrode surfaces (see schematic representation).

KW - Biosensors

KW - Chemiluminescence

KW - DNA

KW - Magnetic particles

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DO - 10.1002/anie.200250379

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IS - 21

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Magnetically amplified DNA assays (MADA): Sensing of viral DNA and single-base mis-matches by using nucleic acid modified magnetic particles

Abstract

Keywords

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