TY - JOUR
T1 - Magnetically responsive carboxylated magnetite-polydipyrrole/ polydicarbazole nanocomposites of core-shell morphology. Preparation, characterization, and use in DNA hybridization
AU - Lellouche, Jean Paul
AU - Senthil, Govindaraji
AU - Joseph, Augustine
AU - Buzhansky, Ludmila
AU - Bruce, Ian
AU - Bauminger, Erika R.
AU - Schlesinger, Jacob
PY - 2005/8/31
Y1 - 2005/8/31
N2 - Novel bis-heterocyclic mono- and dicarboxylated dipyrrole and dicarbazole monomers have been synthesized in a modular manner. Their oxidative polymerization around magnetite nanosized particles has been investigated and optimized toward new magnetic magnetite-polydipyrrole/polydicarbazole nanocomposites (NCs) of a core-shell morphology. These NCs were thoroughly characterized by FT-IR, TGA (Thermal Gravimetric Analysis), low- and high-resolution TEM/HR-TEM microscopies, and Mössbauer spectroscopy along with magnetization studies. Exploiting the versatile COOH chemistry (activation by water-soluble diimides) introduced by the polymeric shell, DNA hybridization experiments have been conducted onto NC surfaces using an efficient blue-colored HRP-based enzymatic screening biological system. Highly parallel NC-supported DNA hybridization experimentations revealed that these NCs presented an interesting potential for DNA-based diagnostic applications.
AB - Novel bis-heterocyclic mono- and dicarboxylated dipyrrole and dicarbazole monomers have been synthesized in a modular manner. Their oxidative polymerization around magnetite nanosized particles has been investigated and optimized toward new magnetic magnetite-polydipyrrole/polydicarbazole nanocomposites (NCs) of a core-shell morphology. These NCs were thoroughly characterized by FT-IR, TGA (Thermal Gravimetric Analysis), low- and high-resolution TEM/HR-TEM microscopies, and Mössbauer spectroscopy along with magnetization studies. Exploiting the versatile COOH chemistry (activation by water-soluble diimides) introduced by the polymeric shell, DNA hybridization experiments have been conducted onto NC surfaces using an efficient blue-colored HRP-based enzymatic screening biological system. Highly parallel NC-supported DNA hybridization experimentations revealed that these NCs presented an interesting potential for DNA-based diagnostic applications.
UR - http://www.scopus.com/inward/record.url?scp=24144476314&partnerID=8YFLogxK
U2 - 10.1021/ja050285l
DO - 10.1021/ja050285l
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C2 - 16117539
AN - SCOPUS:24144476314
SN - 0002-7863
VL - 127
SP - 11998
EP - 12006
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 34
ER -