Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests

Angela Meccariello; Marco Salvemini; Pasquale Primo; Brantley Hall; Panagiota Koskinioti; Martina Dalíková; Andrea Gravina; Michela Anna Gucciardino; Federica Forlenza; Maria Eleni Gregoriou; Domenica Ippolito; Simona Maria Monti; Valeria Petrella; Maryanna Martina Perrotta; Stephan Schmeing; Alessia Ruggiero; Francesca Scolari; Ennio Giordano; Konstantina T. Tsoumani; František Marec; Nikolai Windbichler; Kallare P. Arunkumar; Kostas Bourtzis; Kostas D. Mathiopoulos; Jiannis Ragoussis; Luigi Vitagliano; Zhijian Tu; Philippos Aris Papathanos; Mark D. Robinson; Giuseppe Saccone

doi:10.1126/science.aax1318

Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests

Angela Meccariello, Marco Salvemini, Pasquale Primo, Brantley Hall, Panagiota Koskinioti, Martina Dalíková, Andrea Gravina, Michela Anna Gucciardino, Federica Forlenza, Maria Eleni Gregoriou, Domenica Ippolito, Simona Maria Monti, Valeria Petrella, Maryanna Martina Perrotta, Stephan Schmeing, Alessia Ruggiero, Francesca Scolari, Ennio Giordano, Konstantina T. Tsoumani, František MarecNikolai Windbichler, Kallare P. Arunkumar, Kostas Bourtzis, Kostas D. Mathiopoulos, Jiannis Ragoussis, Luigi Vitagliano, Zhijian Tu, Philippos Aris Papathanos^*, Mark D. Robinson, Giuseppe Saccone

^*Corresponding author for this work

Department of Entomology

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Abstract

In insects, rapidly evolving primary sex-determining signals are transduced by a conserved regulatory module controlling sexual differentiation. In the agricultural pest Ceratitis capitata (Mediterranean fruit fly, or Medfly), we identified a Y-linked gene, Maleness-on-the-Y (MoY), encoding a small protein that is necessary and sufficient for male development. Silencing or disruption of MoY in XY embryos causes feminization, whereas overexpression of MoY in XX embryos induces masculinization. Crosses between transformed XY females and XX males give rise to males and females, indicating that a Ychromosome can be transmitted by XY females. MoY is Y-linked and functionally conserved in other species of the Tephritidae family, highlighting its potential to serve as a tool for developing more effective control strategies against these major agricultural insect pests.

Original language	English
Pages (from-to)	1457-1460
Number of pages	4
Journal	Science
Volume	365
Issue number	6460
DOIs	https://doi.org/10.1126/science.aax1318
State	Published - 27 Sep 2019

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Publisher Copyright:
Copyright © 2019 The Authors.

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Meccariello, A., Salvemini, M., Primo, P., Hall, B., Koskinioti, P., Dalíková, M., Gravina, A., Gucciardino, M. A., Forlenza, F., Gregoriou, M. E., Ippolito, D., Monti, S. M., Petrella, V., Perrotta, M. M., Schmeing, S., Ruggiero, A., Scolari, F., Giordano, E., Tsoumani, K. T., ... Saccone, G. (2019). Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests. Science, 365(6460), 1457-1460. https://doi.org/10.1126/science.aax1318

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title = "Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests",

abstract = "In insects, rapidly evolving primary sex-determining signals are transduced by a conserved regulatory module controlling sexual differentiation. In the agricultural pest Ceratitis capitata (Mediterranean fruit fly, or Medfly), we identified a Y-linked gene, Maleness-on-the-Y (MoY), encoding a small protein that is necessary and sufficient for male development. Silencing or disruption of MoY in XY embryos causes feminization, whereas overexpression of MoY in XX embryos induces masculinization. Crosses between transformed XY females and XX males give rise to males and females, indicating that a Ychromosome can be transmitted by XY females. MoY is Y-linked and functionally conserved in other species of the Tephritidae family, highlighting its potential to serve as a tool for developing more effective control strategies against these major agricultural insect pests.",

author = "Angela Meccariello and Marco Salvemini and Pasquale Primo and Brantley Hall and Panagiota Koskinioti and Martina Dal{\'i}kov{\'a} and Andrea Gravina and Gucciardino, {Michela Anna} and Federica Forlenza and Gregoriou, {Maria Eleni} and Domenica Ippolito and Monti, {Simona Maria} and Valeria Petrella and Perrotta, {Maryanna Martina} and Stephan Schmeing and Alessia Ruggiero and Francesca Scolari and Ennio Giordano and Tsoumani, {Konstantina T.} and Franti{\v s}ek Marec and Nikolai Windbichler and Arunkumar, {Kallare P.} and Kostas Bourtzis and Mathiopoulos, {Kostas D.} and Jiannis Ragoussis and Luigi Vitagliano and Zhijian Tu and Papathanos, {Philippos Aris} and Robinson, {Mark D.} and Giuseppe Saccone",

note = "Publisher Copyright: Copyright {\textcopyright} 2019 The Authors.",

year = "2019",

month = sep,

day = "27",

doi = "10.1126/science.aax1318",

language = "אנגלית",

volume = "365",

pages = "1457--1460",

journal = "Science",

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Meccariello, A, Salvemini, M, Primo, P, Hall, B, Koskinioti, P, Dalíková, M, Gravina, A, Gucciardino, MA, Forlenza, F, Gregoriou, ME, Ippolito, D, Monti, SM, Petrella, V, Perrotta, MM, Schmeing, S, Ruggiero, A, Scolari, F, Giordano, E, Tsoumani, KT, Marec, F, Windbichler, N, Arunkumar, KP, Bourtzis, K, Mathiopoulos, KD, Ragoussis, J, Vitagliano, L, Tu, Z, Papathanos, PA, Robinson, MD & Saccone, G 2019, 'Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests', Science, vol. 365, no. 6460, pp. 1457-1460. https://doi.org/10.1126/science.aax1318

TY - JOUR

T1 - Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests

AU - Meccariello, Angela

AU - Salvemini, Marco

AU - Primo, Pasquale

AU - Hall, Brantley

AU - Koskinioti, Panagiota

AU - Dalíková, Martina

AU - Gravina, Andrea

AU - Gucciardino, Michela Anna

AU - Forlenza, Federica

AU - Gregoriou, Maria Eleni

AU - Ippolito, Domenica

AU - Monti, Simona Maria

AU - Petrella, Valeria

AU - Perrotta, Maryanna Martina

AU - Schmeing, Stephan

AU - Ruggiero, Alessia

AU - Scolari, Francesca

AU - Giordano, Ennio

AU - Tsoumani, Konstantina T.

AU - Marec, František

AU - Windbichler, Nikolai

AU - Arunkumar, Kallare P.

AU - Bourtzis, Kostas

AU - Mathiopoulos, Kostas D.

AU - Ragoussis, Jiannis

AU - Vitagliano, Luigi

AU - Tu, Zhijian

AU - Papathanos, Philippos Aris

AU - Robinson, Mark D.

AU - Saccone, Giuseppe

PY - 2019/9/27

Y1 - 2019/9/27

N2 - In insects, rapidly evolving primary sex-determining signals are transduced by a conserved regulatory module controlling sexual differentiation. In the agricultural pest Ceratitis capitata (Mediterranean fruit fly, or Medfly), we identified a Y-linked gene, Maleness-on-the-Y (MoY), encoding a small protein that is necessary and sufficient for male development. Silencing or disruption of MoY in XY embryos causes feminization, whereas overexpression of MoY in XX embryos induces masculinization. Crosses between transformed XY females and XX males give rise to males and females, indicating that a Ychromosome can be transmitted by XY females. MoY is Y-linked and functionally conserved in other species of the Tephritidae family, highlighting its potential to serve as a tool for developing more effective control strategies against these major agricultural insect pests.

AB - In insects, rapidly evolving primary sex-determining signals are transduced by a conserved regulatory module controlling sexual differentiation. In the agricultural pest Ceratitis capitata (Mediterranean fruit fly, or Medfly), we identified a Y-linked gene, Maleness-on-the-Y (MoY), encoding a small protein that is necessary and sufficient for male development. Silencing or disruption of MoY in XY embryos causes feminization, whereas overexpression of MoY in XX embryos induces masculinization. Crosses between transformed XY females and XX males give rise to males and females, indicating that a Ychromosome can be transmitted by XY females. MoY is Y-linked and functionally conserved in other species of the Tephritidae family, highlighting its potential to serve as a tool for developing more effective control strategies against these major agricultural insect pests.

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DO - 10.1126/science.aax1318

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C2 - 31467189

AN - SCOPUS:85072710875

SN - 0036-8075

VL - 365

SP - 1457

EP - 1460

JO - Science

JF - Science

IS - 6460

ER -

Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests

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