TY - JOUR
T1 - Malignant appendiceal GIST
T2 - Case report and review of the literature
AU - Elazary, Ram
AU - Schlager, Avraham
AU - Khalaileh, Abed
AU - Appelbaum, Liat
AU - Bala, Miklosh
AU - Abu-Gazala, Mahmoud
AU - Khatib, Areej
AU - Neuman, Tzahi
AU - Rivkind, Avraham I.
AU - Almogy, Gidon
PY - 2010/3
Y1 - 2010/3
N2 - Introduction: Gastro-intestinal stromal tumors (GISTs) of the appendix are a rare entity. To date, only a handful has been described in the literature, all of which have been of the benign type. Case Report: We present the first reported case of a malignant appendiceal GIST. The tumor was discovered when the patient presented with a peri-appendiceal abscess which appeared suspicious on CT. The abscess was drained and managed medically. The patient responded to antibiotic treatment but subsequent CT and biopsy confirmed the diagnosis of appendiceal GIST, and the patient was started on treatment with imatinab mesylate. Discussion: One week after initiation of therapy, the patient returned with frank peritonitis necessitating surgery. Abdominal exploration revealed an appendiceal GIST locally invading and perforating adjacent bowel. We describe the complex presentation and course of the case as well as a literature review of the appendiceal GISTs and the current approach to treatment.
AB - Introduction: Gastro-intestinal stromal tumors (GISTs) of the appendix are a rare entity. To date, only a handful has been described in the literature, all of which have been of the benign type. Case Report: We present the first reported case of a malignant appendiceal GIST. The tumor was discovered when the patient presented with a peri-appendiceal abscess which appeared suspicious on CT. The abscess was drained and managed medically. The patient responded to antibiotic treatment but subsequent CT and biopsy confirmed the diagnosis of appendiceal GIST, and the patient was started on treatment with imatinab mesylate. Discussion: One week after initiation of therapy, the patient returned with frank peritonitis necessitating surgery. Abdominal exploration revealed an appendiceal GIST locally invading and perforating adjacent bowel. We describe the complex presentation and course of the case as well as a literature review of the appendiceal GISTs and the current approach to treatment.
KW - Appendix
KW - C-kit
KW - Gastrointestinal stromal tumor
KW - Imatinib mesylate
UR - http://www.scopus.com/inward/record.url?scp=77950189186&partnerID=8YFLogxK
U2 - 10.1007/s12029-009-9113-8
DO - 10.1007/s12029-009-9113-8
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C2 - 19960274
AN - SCOPUS:77950189186
SN - 1941-6628
VL - 41
SP - 9
EP - 12
JO - Journal of Gastrointestinal Cancer
JF - Journal of Gastrointestinal Cancer
IS - 1
ER -