Mammals have multiple genes for individual ribosomal proteins

Raymond J. Monk; Oded Meyuhas; Robert P. Perry

doi:10.1016/0092-8674(81)90319-6

Mammals have multiple genes for individual ribosomal proteins

Raymond J. Monk^*, Oded Meyuhas, Robert P. Perry

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

The reiteration frequency of the genes that encode the structural proteins of the mammalian ribosome was studied with a set of cloned cDNA probes containing several different mouse r-protein mRNA sequences. Results from a reassociation kinetics analysis, Southern blotting experiments and gene cloning studies collectively indicate that each individual r-protein species is represented by multiple genes in mammals. Among the examples studied, the multiplicity of mouse r-protein genes varied from about 7 to 20, a striking contrast to the low copy numbers observed in less evolutionarily advanced eucaryotes. The multiplicity of individual r-protein genes in humans and rodents is similar.

Original language	English
Pages (from-to)	301-306
Number of pages	6
Journal	Cell
Volume	24
Issue number	2
DOIs	https://doi.org/10.1016/0092-8674(81)90319-6
State	Published - May 1981

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Mammals have multiple genes for individual ribosomal proteins

Abstract

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