Manipulation of metastasis and tumour growth by transfection with histocompatibility class I genes

G J Hämmerling; D Klar; S Katzav; S Segal; M Feldman; R Wallich; A Hämmerling

doi:10.1111/j.1744-313x.1986.tb01096.x

Manipulation of metastasis and tumour growth by transfection with histocompatibility class I genes

G J Hämmerling, D Klar, S Katzav, S Segal, M Feldman, R Wallich, A Hämmerling

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Approximately 50% of fibrosarcomas induced with methylcholanthrene A were found to be defective in H-2 expression. In tumours which lack H-2K antigens, H-2 gene transfection was used to restore H-2K expression. The de novo expression of H-2K reduced tumorigenicity and abolished the formation of metastases in syngeneic mice. Expression of H-2K seems to render the tumour cells immunogenic and leads to effective recognition of the tumour cells by the host immune system.

Original language	English
Pages (from-to)	153-7
Number of pages	5
Journal	Journal of Immunogenetics
Volume	13
Issue number	2-3
DOIs	https://doi.org/10.1111/j.1744-313x.1986.tb01096.x
State	Published - 1986
Externally published	Yes

Keywords

Animals
Fibrosarcoma/genetics
H-2 Antigens/genetics
Methylcholanthrene
Mice
Neoplasm Metastasis
Transfection

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10.1111/j.1744-313x.1986.tb01096.x

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title = "Manipulation of metastasis and tumour growth by transfection with histocompatibility class I genes",

abstract = "Approximately 50% of fibrosarcomas induced with methylcholanthrene A were found to be defective in H-2 expression. In tumours which lack H-2K antigens, H-2 gene transfection was used to restore H-2K expression. The de novo expression of H-2K reduced tumorigenicity and abolished the formation of metastases in syngeneic mice. Expression of H-2K seems to render the tumour cells immunogenic and leads to effective recognition of the tumour cells by the host immune system.",

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author = "H{\"a}mmerling, {G J} and D Klar and S Katzav and S Segal and M Feldman and R Wallich and A H{\"a}mmerling",

year = "1986",

doi = "10.1111/j.1744-313x.1986.tb01096.x",

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journal = "Journal of Immunogenetics",

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T1 - Manipulation of metastasis and tumour growth by transfection with histocompatibility class I genes

AU - Hämmerling, G J

AU - Klar, D

AU - Katzav, S

AU - Segal, S

AU - Feldman, M

AU - Wallich, R

AU - Hämmerling, A

PY - 1986

Y1 - 1986

N2 - Approximately 50% of fibrosarcomas induced with methylcholanthrene A were found to be defective in H-2 expression. In tumours which lack H-2K antigens, H-2 gene transfection was used to restore H-2K expression. The de novo expression of H-2K reduced tumorigenicity and abolished the formation of metastases in syngeneic mice. Expression of H-2K seems to render the tumour cells immunogenic and leads to effective recognition of the tumour cells by the host immune system.

AB - Approximately 50% of fibrosarcomas induced with methylcholanthrene A were found to be defective in H-2 expression. In tumours which lack H-2K antigens, H-2 gene transfection was used to restore H-2K expression. The de novo expression of H-2K reduced tumorigenicity and abolished the formation of metastases in syngeneic mice. Expression of H-2K seems to render the tumour cells immunogenic and leads to effective recognition of the tumour cells by the host immune system.

KW - Animals

KW - Fibrosarcoma/genetics

KW - H-2 Antigens/genetics

KW - Methylcholanthrene

KW - Mice

KW - Neoplasm Metastasis

KW - Transfection

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JO - Journal of Immunogenetics

JF - Journal of Immunogenetics

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Manipulation of metastasis and tumour growth by transfection with histocompatibility class I genes

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Keywords

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