Manipulation of the human genome in human embryonic stem cells

Oded Kopper; Nissim Benvenisty

doi:10.1385/SCR:1:2:145

Manipulation of the human genome in human embryonic stem cells

Oded Kopper, Nissim Benvenisty^*

^*Corresponding author for this work

Department of Genetics

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Human embryonic stem cells (HESCs) have a tremendous clinical and scientific importance since they may serve as a cell source for transplantation and as a system for the study of human development and disease. The genetic engineering of HESCs has become instrumental in achieving these goals. Here we discuss various methodologies to genetically manipulate HESCs and propose a variety of applications of the modified cells in basic and applied research.

Original language	English
Pages (from-to)	145-150
Number of pages	6
Journal	Stem Cell Reviews
Volume	1
Issue number	2
DOIs	https://doi.org/10.1385/SCR:1:2:145
State	Published - Jun 2005

Bibliographical note

Funding Information:
Acknowledgments We thank Tamar Dvash, Yoav Mishar, and Dr. Rachel Eiges for their valuable assistance. This research was partially supported by funds from the Israel Ministry of Science and by a grant from the Israel Science Foundation (Grant No. 672/02–1).

Keywords

Embryonic stem cell
Genetic manipulation
Human genetics
Infection
Model for human disease
Transfection

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10.1385/SCR:1:2:145

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abstract = "Human embryonic stem cells (HESCs) have a tremendous clinical and scientific importance since they may serve as a cell source for transplantation and as a system for the study of human development and disease. The genetic engineering of HESCs has become instrumental in achieving these goals. Here we discuss various methodologies to genetically manipulate HESCs and propose a variety of applications of the modified cells in basic and applied research.",

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Manipulation of the human genome in human embryonic stem cells

Abstract

Bibliographical note

Keywords

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