Manipulation of the human genome in human embryonic stem cells

Oded Kopper, Nissim Benvenisty*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Human embryonic stem cells (HESCs) have a tremendous clinical and scientific importance since they may serve as a cell source for transplantation and as a system for the study of human development and disease. The genetic engineering of HESCs has become instrumental in achieving these goals. Here we discuss various methodologies to genetically manipulate HESCs and propose a variety of applications of the modified cells in basic and applied research.

Original languageAmerican English
Pages (from-to)145-150
Number of pages6
JournalStem Cell Reviews
Issue number2
StatePublished - Jun 2005

Bibliographical note

Funding Information:
Acknowledgments We thank Tamar Dvash, Yoav Mishar, and Dr. Rachel Eiges for their valuable assistance. This research was partially supported by funds from the Israel Ministry of Science and by a grant from the Israel Science Foundation (Grant No. 672/02–1).


  • Embryonic stem cell
  • Genetic manipulation
  • Human genetics
  • Infection
  • Model for human disease
  • Transfection


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